Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790646 | 0.98 | FDPS (0.97) | FDPSMAPTFDFT1NPC1RAB9A | |
| SCHEMBL9790662 | 0.89 | FDPS (0.80) | FDPSMAPTFDFT1NPC1RAB9A | |
| SCHEMBL9790685 | 0.76 | FDPS (0.61) | FDPSMAPTNPC1RAB9AHPGD | |
| SCHEMBL13351522 | 0.74 | FDPS (0.59) | FDPSMAPTNPC1RAB9AHPGD | |
| SCHEMBL2777930 | 0.74 | FDPS (0.58) | FDPSMAPTNPC1RAB9AHPGD | |
| SCHEMBL9790602 | 0.73 | FDPS (0.57) | FDPSMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9790564 | 0.72 | FDPS (0.56) | FDPSMAPTNPC1RAB9ASMN1; SMN2 | |
| Phosphonic Acid SCHEMBL9790670 | 0.70 | FDPS (0.54) | FDPSMAPTNPC1RAB9AHPGD | |
| SCHEMBL6222634 | 0.69 | FDPS (0.53) | FDPSMAPTFDFT1NPC1RAB9A | |
| SCHEMBL12921530 | 0.69 | FDPS (0.53) | FDPSMAPTNPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274346-B1 | SUBSTITUTED AMINOMETHANE-DIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | claimed |
| EP-0274346-A1 | Substituted aminomethane-diphosphonic acids | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | claimed |
| US-5057505-A | Treatment of illnesses attributed to calcium metabolism disorders | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0282309-A2 | Azole-aminomethylene bisphosphonic acid derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-14 | — | — | EP | disclosed |
| EP-0274346-A1 | Substituted aminomethane-diphosphonic acids | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | disclosed |