Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 2/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113434 | 0.86 | CES2 (0.67) | NOTUMCES2ACHEMLYCDCES1 | |
| SCHEMBL2560056 | 0.86 | CES1 (0.48) | NOTUMACHEMLYCDCES1 | |
| SCHEMBL13095524 | 0.85 | ACHE (0.57) | NOTUMACHEMLYCDCES1DDR1 | |
| SCHEMBL31144857 | 0.85 | NOTUM (0.62) | NOTUMCES2ACP1DDR1TAS2R14 | |
| SCHEMBL627581 | 0.85 | NOTUM (0.62) | NOTUMCES2ACP1DDR1TAS2R14 | |
| SCHEMBL494019 | 0.82 | NOTUM (0.64) | NOTUMCES2ACP1DDR1TAS2R14 | |
| SCHEMBL30253392 | 0.81 | NOTUM (0.62) | NOTUMCES2ACP1CES1DDR1 | |
| SCHEMBL766077 | 0.81 | NOTUM (0.67) | NOTUMCES2ACP1DDR1TAS2R14 | |
| SCHEMBL477562 | 0.81 | NOTUM (0.62) | NOTUMCES2ACP1CES1DDR1 | |
| SCHEMBL27856957 | 0.81 | NOTUM (0.62) | NOTUMCES2ACP1CES1DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105566089-B | The method for being used to prepare 3- trifluoromethyl chalcones | 杜邦公司 | 2019-07-02 | — | — | CN | claimed |
| EP-2706053-B1 | Method for preparing 2-trifluoromethyl ketones | DU PONT (US) | 2016-10-26 | — | — | EP | claimed |
| CN-105646215-A | Method for preparing 3-trifluoromethyl chalcones | 杜邦公司 | 2016-06-08 | — | — | CN | claimed |
| EP-2706053-A1 | Method for preparing 2-trifluoromethyl ketones | E. I. du Pont de Nemours and Company (US) | 2014-03-12 | — | — | EP | claimed |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E.I. DU PONT DE NEMOURS AND COMPANY (DE) | 2011-01-13 | — | — | US | claimed |
| CN-113651710-B | Preparation method of 3, 5-substituted-4-amino trifluoroacetophenone and derivatives thereof | 台州臻挚生物科技有限公司 | 2024-06-21 | — | — | CN | disclosed |
| EP-3013808-B1 | ISOTHIAZOLINE COMPOUNDS SUBSTITUTED WITH A CARBOBICYCLIC GROUP | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-3013807-B1 | NAPHTHYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2020-04-08 | — | — | EP | disclosed |
| CN-105566089-B | The method for being used to prepare 3- trifluoromethyl chalcones | 杜邦公司 | 2019-07-02 | — | — | CN | disclosed |
| US-10327446-B2 | Naphthyl- or isoquinolinyl-substituted isothiazoline compounds | Boehringer Ingelheim Animal Health USA Inc. (US) | 2019-06-25 | — | — | US | disclosed |
| US-20160374342-A1 | Naphthyl- or isoquinolinyl-substituted isothiazoline compounds | MERIAL, INC. (US) | 2016-12-29 | — | — | US | disclosed |
| EP-2706053-B1 | Method for preparing 2-trifluoromethyl ketones | DU PONT (US) | 2016-10-26 | — | — | EP | disclosed |
| WO-2014029707-A1 | METHODS OF CONTROLLING INSECTS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-02-27 | — | — | WO | disclosed |
| US-8318757-B2 | Substituted isoxazoline compound and pest control agent | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-11-27 | — | — | US | disclosed |
| US-8242283-B2 | Isoxazoline compound and pesticide | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-08-14 | — | — | US | disclosed |
| US-20110172414-A1 | ISOXAZOLINE COMPOUND AND PESTICIDE | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-07-14 | — | — | US | disclosed |
| US-7947715-B2 | Isoxazoline compound and pesticide | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-20110009438-A1 | SUBSTITUTED ISOXAZOLINE COMPOUND AND PEST CONTROL AGENT | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-01-13 | — | — | US | disclosed |
| EP-2199287-A1 | SUBSTITUTED ISOXAZOLINE COMPOUND AND PEST CONTROL AGENT | Nissan Chemical Industries, Ltd. (JP) | 2010-06-23 | — | — | EP | disclosed |
| US-20090156643-A1 | Substituted isoxazoline compound and pesticide | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172414-A1 | ISOXAZOLINE COMPOUND AND PESTICIDE | HCRTR1, HAX1, CHRM1 | NOTUM 854/4885CES2 959/4885ACHE 113/4885 |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | NOTUM 1579/4885CES2 1616/4885ACHE 2411/4885 |
| US-20090156643-A1 | Substituted isoxazoline compound and pesticide | HCRTR1, CBR1, CHRM1 | NOTUM 914/4885CES2 867/4885ACHE 79/4885 |
| US-20160374342-A1 | Naphthyl- or isoquinolinyl-substituted isothiazoline compounds | IPO5, SNX1, IPO9 | NOTUM 382/4885CES2 3003/4885ACHE 55/4885 |
| US-20110009438-A1 | SUBSTITUTED ISOXAZOLINE COMPOUND AND PEST CONTROL AGENT | CCR10, H1-10, CCL11 | NOTUM 3342/4885CES2 1100/4885ACHE 347/4885 |
| US-10327446-B2 | Naphthyl- or isoquinolinyl-substituted isothiazoline compounds | IPO5, SNX1, IPO9 | NOTUM 382/4885CES2 3003/4885ACHE 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.