Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27281896 | 0.83 | L3MBTL1 (0.42) | TSHRHSD17B10LTA4HALOX15MAPT | |
| SCHEMBL11165253 | 0.79 | ALDH1A1 (0.43) | TSHRHSD17B10ALOX5LTA4HALOX15 | |
| SCHEMBL27882736 | 0.78 | LTA4H (0.41) | TSHRHSD17B10LTA4HTP53L3MBTL1 | |
| SCHEMBL27404289 | 0.77 | LTA4H (0.40) | TSHRHSD17B10LTA4HTP53MAPT | |
| SCHEMBL27918079 | 0.75 | LTA4H (0.38) | TSHRHSD17B10LTA4HTP53L3MBTL1 | |
| SCHEMBL19693446 | 0.75 | TP53 (0.43) | TSHRHSD17B10ALOX5TP53ALOX15 | |
| SCHEMBL8066258 | 0.75 | LTA4H (0.35) | TSHRHSD17B10LTA4HMAPTLMNA | |
| SCHEMBL1045799 | 0.73 | TP53 (0.38) | TSHRHSD17B10LTA4HTP53L3MBTL1 | |
| SCHEMBL11504408 | 0.72 | LTA4H (0.38) | TSHRHSD17B10ALOX5LTA4HTP53 | |
| SCHEMBL10654697 | 0.71 | L3MBTL1 (0.37) | TSHRHSD17B10ALOX5LTA4HTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051446-A | Cardiovascular disorders | E. I. DU PONT DE NEMOURS & CO. (US) | 1991-09-24 | — | — | US | claimed |
| EP-0041492-B1 | NEW SUBSTITUTED 3-PHENOXY-1-ALKOXYCARBONYL-ALKYLAMINO-PROPANOL-2-S HAVING BETA RECEPTOR BLOCKING PROPERTIES | Aktiebolaget Hässle (SE) | 1985-03-20 | — | — | EP | claimed |
| EP-0041491-B1 | NEW PARA-SUBSTITUTED 3-PHENOXY-1-ALKYLAMINO-PROPANOL-2-S HAVING BETA RECEPTOR BLOCKING PROPERTIES | Aktiebolaget Hässle (SE) | 1985-01-30 | — | — | EP | claimed |
| EP-0064487-A1 | New substituted 3-(parasubstituted)phenoxy-1-alkylamino-propanol-2-s, as well as process for their preparation, pharmaceutical preparations containing same, and method for treating cardiac failure | Aktiebolaget Hässle (SE) | 1982-11-10 | — | — | EP | claimed |
| EP-0041491-A1 | New para-substituted 3-phenoxy-1-alkylamino-propanol-2-s having beta receptor blocking properties | Aktiebolaget Hässle (SE) | 1981-12-09 | — | — | EP | claimed |
| US-4263323-A | β-Receptor blocking compounds and treatment of cardiovascular disorders therewith | AKTIEBOLAGET HASSLE (SE) | 1981-04-21 | — | — | US | claimed |
| US-4263325-A | PHENOXY- AMINE DERIVATIVES | AKTIEBOLAGET HASSLE (SE) | 1981-04-21 | — | — | US | claimed |
| EP-0007294-A2 | Membrane stabilizing compounds having beta-receptor blocking activity, their preparation, method for treatment of arrhythmic conditions, and pharmaceutical preparations containing same | Aktiebolaget Hässle (SE) | 1980-01-23 | — | — | EP | claimed |
| US-4161542-A | 3-(2-/P-HYDROXYPHENYL/-1-METHYLETHYLAMINO)-1-PHENOXY-2-PROPANOL/; | AKTIEBOLAGET HASSLE (SE) | 1979-07-17 | — | — | US | claimed |
| US-4145442-A | ADRENERGIC STIMULANTS; ANTAGONIST, ANTAGONISM | AKTIEBOLAGET HASSLE (SE) | 1979-03-20 | — | — | US | claimed |
| US-3996382-A | Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases | AKTIEBOLAGET HASSLE (SW) | 1976-12-07 | — | — | US | claimed |
| CN-1087630-A | Dihydrogen pyridine derivative and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-06-08 | — | — | CN | disclosed |
| EP-0071535-B1 | (4-(2 AND/OR 3-THIENYLACETAMIDO)-PHENOXY)-HYDROXYAMINOPROPANES, THEIR PREPARATION, THEIR THERAPEUTIC USE AND INTERMEDIATES | CARPIBEM (CENTRE D'ACTIVITE ET DE RECHERCHE PHARMACEUTIQUE INDUSTRIELLE BIOLOGIQUE ET MEDICALE) Société Anonyme dite: (FR) | 1987-01-14 | — | — | EP | disclosed |
| US-4450172-A | VASODILATION; HYPOTENSIVE AND CARDIOTONIC AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-05-22 | — | — | US | disclosed |
| US-4376125-A | Aminobenzlpropranolol and pharmaceutical preparation thereof | UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) | 1983-03-08 | — | — | US | disclosed |
| US-3996382-A | Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases | AKTIEBOLAGET HASSLE (SW) | 1976-12-07 | — | — | US | disclosed |
| US-3996382-A | Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases | AKTIEBOLAGET HASSLE (SW) | 1976-12-07 | — | — | US | disclosed |
| US-3928601-A | Phenoxy-hydroxypropylamines, method and pharmaceutical preparations for treating cardiovascular diseases | HAESSLE AB | 1975-12-23 | — | — | US | disclosed |
| US-3928601-A | Phenoxy-hydroxypropylamines, method and pharmaceutical preparations for treating cardiovascular diseases | HAESSLE AB | 1975-12-23 | — | — | US | disclosed |
| US-3873600-A | Phenoxycarbamates | BRANDSTROM ARNE ELOF | 1975-03-25 | — | — | US | disclosed |