Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | CA12 | O43570 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA4 | P22748 | 4/20 | 0.33 |
| ▸ | CA9 | Q16790 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9795102 | 0.91 | MEN1 (0.38) | PDE5APTGS2PTGS1CA2CA1 | |
| Fumaric Acid SCHEMBL9795038 | 0.89 | BCHE (0.38) | PDE5ARECQLPTGS2PTGS1BCHE | |
| Fumaric Acid SCHEMBL9795267 | 0.87 | TSHR (0.40) | PDE5APTGS2PTGS1BCHEACHE | |
| SCHEMBL3399298 | 0.86 | CA2 (0.40) | PTGS2PTGS1BCHEACHECA2 | |
| Fumaric Acid SCHEMBL9795207 | 0.85 | SLC6A5 (0.37) | PDE5ABCHEACHECA2CA1 | |
| Hydrochloric Acid SCHEMBL3310219 | 0.84 | CA2 (0.39) | PTGS2PTGS1BCHEACHECA2 | |
| Fumaric Acid SCHEMBL9795144 | 0.82 | PDE5A (0.37) | PDE5ARECQLPTGS2PTGS1BCHE | |
| Fumaric Acid SCHEMBL9795581 | 0.80 | TSHR (0.36) | PDE5APTGS2PTGS1BCHEACHE | |
| Fumaric Acid SCHEMBL9795218 | 0.80 | CA1 (0.36) | PDE5ABCHEACHECA2CA1 | |
| Fumaric Acid SCHEMBL9795249 | 0.79 | CYP2C19 (0.39) | PDE5APTGS2PTGS1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |