Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26964538 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10KMT2ALMNA | |
| SCHEMBL558515 | 0.70 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10KMT2ALMNA | |
| SCHEMBL9517782 | 0.69 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10KMT2AHPGD | |
| SCHEMBL9525882 | 0.69 | TGFBR1 (0.46) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| Bromide SCHEMBL1186616 | 0.68 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10KMT2ALMNA | |
| SCHEMBL11490669 | 0.67 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10KMT2ALMNA | |
| SCHEMBL9796329 | 0.67 | CA1 (0.43) | ALDH1A1KMT2AGAAPTGS1PTGS2 | |
| SCHEMBL25261995 | 0.67 | KMT2A (0.51) | KDM4EALDH1A1HSD17B10KMT2AHPGD | |
| SCHEMBL9517202 | 0.67 | ALDH1A1 (0.44) | KDM4EALDH1A1HSD17B10KMT2AHPGD | |
| SCHEMBL20674623 | 0.67 | LDHA (0.36) | KDM4EALDH1A1HSD17B10KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990523-A | Treatment of chronic inflammatory joint disease with arylsulfonamides | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-02-05 | — | — | US | disclosed |
| WO-1990015600-A2 | TREATMENT OF CHRONIC INFLAMMATORY JOINT DISEASE WITH ARYLSULFONAMIDES | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-12-27 | — | — | WO | disclosed |