Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | YAP1 | P46937 | 1/20 | 0.49 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.49 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605325 | 0.82 | KDM4E (0.58) | KDM4EPOLBATMALDH1A1KMT2A | |
| SCHEMBL19131301 | 0.82 | KDM4E (0.58) | KDM4EPOLBATMALDH1A1KMT2A | |
| SCHEMBL5634989 | 0.82 | KDM4E (0.50) | KDM4EPOLBATMYAP1TEAD4 | |
| SCHEMBL8752477 | 0.81 | CYP2C19 (0.59) | KDM4EPOLBALDH1A1MAPK1HIF1A | |
| SCHEMBL12809405 | 0.81 | KDM4E (0.56) | KDM4EPOLBATMALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL8584876 | 0.81 | KDM4E (0.56) | KDM4EPOLBATMALDH1A1KMT2A | |
| SCHEMBL11427052 | 0.81 | KDM4E (0.56) | KDM4EPOLBATMALDH1A1KMT2A | |
| SCHEMBL8704902 | 0.80 | KMT2A (0.61) | KDM4EATMALDH1A1MAPK1KMT2A | |
| SCHEMBL11737575 | 0.79 | ALDH1A1 (0.61) | KDM4EPOLBYAP1TEAD4TEAD2 | |
| SCHEMBL7835113 | 0.78 | YAP1 (0.65) | KDM4EYAP1TEAD4TEAD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045539-A | 1H-indolo[3,2-c]quinoline-derivatives, compositions containing same, useful for treating pain, psychosis or convulsions | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-09-03 | — | — | US | disclosed |
| US-5006531-A | 5,6-dihydro(1H-indolo(3,2-C)quinoline-6,4'-piperidines) and related compounds which are useful for treating pain, psychosis or convulsions | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0407898-A1 | 5,6-dihydro(1H-indolo(3,2-c)quinoline-6,4-piperidines)and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-16 | — | — | EP | disclosed |
| EP-0330340-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |