Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 3/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378744 | 0.83 | HSD17B10 (0.43) | EGFRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9688263 | 0.82 | IL1R1 (0.47) | KDM4EALDH1A1MEN1GLACASP1 | |
| Hydrochloric Acid SCHEMBL10377764 | 0.81 | ALDH1A1 (0.48) | KDM4EALDH1A1MEN1KMT2AALB | |
| SCHEMBL9688855 | 0.81 | RAB9A (0.47) | ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL9688069 | 0.81 | HPGD (0.47) | EGFRKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7274363 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1GLAHPGD | |
| SCHEMBL10379104 | 0.79 | SIGMAR1 (0.44) | ALBBCHEACHE | |
| Hydrochloric Acid SCHEMBL10379123 | 0.78 | SIGMAR1 (0.43) | ALBBCHEACHEMAPT | |
| SCHEMBL10472793 | 0.77 | MTNR1A (0.45) | ALDH1A1HPGD | |
| SCHEMBL10378819 | 0.77 | F9 (0.39) | EGFRKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987137-A | CEREBRAL SENILITY | BEECHAM WUELFING GMBH & CO., KG (DE) | 1991-01-22 | — | — | US | disclosed |
| EP-0167901-B1 | ACTIVE COMPOUNDS | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-04-04 | — | — | EP | disclosed |
| US-4853391-A | Pyrido[1,2-a]indoles and their use as cardiovascular | LABORATOIRES SOBIO SA, 13-15-25 BOULEVARD DE 1'AMIRAL BRUIX 75782 PARIS, CEDEX 16, FRANCE | 1989-08-01 | — | — | US | disclosed |
| US-4837240-A | ANTIISCHEMIC, ANTHIHYPOXIC AGENTS | BEECHAM-WUELFING GMBH & CO. KG (FR) | 1989-06-06 | — | — | US | disclosed |
| US-4835271-A | Aminoalkyl secocanthine derivatives and their use | BEECHAM-WUELFING GMBH & CO., KG (DE) | 1989-05-30 | — | — | US | disclosed |
| EP-0252643-A1 | Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-01-13 | — | — | EP | disclosed |
| EP-0213696-A2 | Tetrahydropyrido [1,2-a] indole derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Beecham Wuelfing GmbH & Co KG (DE) | 1987-03-11 | — | — | EP | disclosed |