Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400325 | 0.90 | GABRA1 (0.61) | GABRA1GABRB1HSD17B10TSHRALDH1A1 | |
| SCHEMBL11682443 | 0.85 | GABRA1 (0.55) | GABRA1GABRB1HSD17B10TSHRALDH1A1 | |
| SCHEMBL11679871 | 0.81 | GABRA1 (0.47) | GABRA1GABRB1HSD17B10TSHRALDH1A1 | |
| SCHEMBL12767956 | 0.79 | GABRA1 (0.78) | GABRA1GABRB1HSD17B10TSHRALDH1A1 | |
| SCHEMBL2168125 | 0.79 | RORC (0.46) | GABRA1GABRB1HSD17B10TSHRALDH1A1 | |
| SCHEMBL2974180 | 0.78 | GABRA1 (0.56) | GABRA1GABRB1HSD17B10TSHRALDH1A1 | |
| SCHEMBL23159332 | 0.77 | GABRA1 (0.36) | GABRA1GABRB1TSHRALDH1A1RORC | |
| SCHEMBL17069214 | 0.77 | GABRA1 (0.36) | GABRA1GABRB1TSHRALDH1A1RORC | |
| SCHEMBL9797748 | 0.77 | GABRA1 (0.36) | GABRA1GABRB1TSHRALDH1A1RORC | |
| SCHEMBL9811656 | 0.75 | TDP1 (0.38) | GABRA1GABRB1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236082-B2 | EZH2 inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
| US-20190192532-A1 | COMBINATION THERAPY OF BROMODOMAIN INHIBITORS AND CHECKPOINT BLOCKADE | PETER MACCALLUM CANCER INSTITUTE (AU) | 2019-06-27 | — | — | US | disclosed |
| US-5064861-A | ACYLATED AMINE COMPOUNDS WHICH ARE USEFUL FUNGICIGAL AGENTS | ROUSSEL UCLAF (FR) | 1991-11-12 | — | — | US | disclosed |
| EP-0413807-A1 | ACYLATED POLYAMINES AND APPLICATIONS THEREOF AS VEGETABLE GROWTH REGULATORS | ROUSSEL-UCLAF (FR) | 1991-02-27 | — | — | EP | disclosed |
| WO-1990010386-A1 | ACYLATED POLYAMINES AND APPLICATIONS THEREOF AS VEGETABLE GROWTH REGULATORS | ROUSSEL-UCLAF (FR) | 1990-09-20 | — | — | WO | disclosed |
| EP-0376819-A1 | Acrylated polyamines, process for their preparation and their use as fungicides | ROUSSEL-UCLAF (FR) | 1990-07-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | GABRA1 2555/4885GABRB1 1643/4885HSD17B10 392/4885 |
| US-20190192532-A1 | COMBINATION THERAPY OF BROMODOMAIN INHIBITORS AND CHECKPOINT BLOCKADE | BRD4, BRD3, BRPF3 | GABRA1 1251/4885GABRB1 1430/4885HSD17B10 4028/4885 |
| US-11236082-B2 | EZH2 inhibitors and uses thereof | EZH2, EZH1, BMI1 | GABRA1 3067/4885GABRB1 2489/4885HSD17B10 1441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.