Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.48 |
| ▸ | CA1 | P00915 | 8/20 | 0.44 |
| ▸ | CA9 | Q16790 | 7/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11137088 | 0.84 | CA2 (0.60) | CA2CA1CA9CA12CA7 | |
| SCHEMBL8091196 | 0.79 | CA2 (0.67) | CA2CA1CA9CA12CA7 | |
| SCHEMBL1138688 | 0.78 | PLCG1 (0.46) | CA2CA1CA9CA12CA7 | |
| SCHEMBL9200717 | 0.78 | PLCG1 (0.46) | CA2CA1CA9CA12CA7 | |
| SCHEMBL2028261 | 0.74 | PLCG1 (0.43) | CA2CA1CA9CA12CA7 | |
| SCHEMBL9421744 | 0.74 | FAAH (0.60) | CA2CA1CA9CA12CA7 | |
| SCHEMBL9629254 | 0.74 | IDO1 (0.43) | CA2CA1CA9CA12CA7 | |
| SCHEMBL6466 | 0.74 | EGFR (0.43) | CA2CA1CA9CA12CA7 | |
| SCHEMBL13196 | 0.74 | NPC1 (0.44) | CA2CA1CA9CA12CA7 | |
| SCHEMBL9000869 | 0.73 | EGFR (0.42) | CA2CA1CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252640-B1 | ALKANESULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4812463-A | CARBONIC ANHYDRASE INHIBITORS | MERCK & CO., INC. (US) | 1989-03-14 | — | — | US | disclosed |
| EP-0252640-A1 | Alkanesulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1988-01-13 | — | — | EP | disclosed |