Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mequinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000565 | 0.88 | NPC1 (0.53) | ESR2LTA4HMEN1CYP3A4KMT2A | |
| Methoxymethane SCHEMBL9836653 | 0.86 | HSD17B10 (0.54) | ESR2ESR1CYP3A4ALDH1A1HPGD | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL9799771 | 0.84 | ESR1 (0.50) | ESR2ESR1MEN1CYP3A4KMT2A | |
| SCHEMBL29353342 | 0.81 | — | — | |
| SCHEMBL6563191 | 0.81 | HSD17B10 (0.65) | ESR2ESR1MEN1CYP3A4KMT2A | |
| SCHEMBL33883 | 0.81 | — | — | |
| Mequinol SCHEMBL28063063 | 0.79 | ESR2 (0.76) | ESR2LTA4HAPPESR1MEN1 | |
| Hydrochloric Acid SCHEMBL29135541 | 0.79 | HSD17B10 (0.62) | ESR2ESR1MEN1CYP3A4KMT2A | |
| Mequinol SCHEMBL21009 | 0.78 | — | — | |
| Mequinol SCHEMBL166535 | 0.78 | ESR2 (0.84) | ESR2LTA4HAPPESR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5024921-A | Thermally stable light-sensitive compositions with o-quinone diazide and phenolic resin used in a method of forming a positive photoresist image | OCG MICROELECTRONIC MATERIALS, INC. (US) | 1991-06-18 | — | — | US | disclosed |
| US-4970287-A | 4-HALORESORCINOL AND 2,6-DIMETHYLOLPHENOL MONOMERS; LIGH SENSITIVE COMPOUNDS | OLIN HUNT SPECIALTY PRODUCTS INC. (US) | 1990-11-13 | — | — | US | disclosed |
| US-4837121-A | POSITIVE-WORKING PHOTORESISTS | OLIN HUNT SPECIALTY PRODUCTS INC. (US) | 1989-06-06 | — | — | US | disclosed |