Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mequinol SCHEMBL9799436 | 0.88 | ESR2 (0.55) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL9799771 | 0.83 | ESR1 (0.50) | NPC1ALDH1A1CYP3A4GAAMAPT | |
| SCHEMBL754809 | 0.82 | ALDH1A1 (0.55) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| Methoxymethane SCHEMBL9836653 | 0.79 | HSD17B10 (0.54) | ALDH1A1CYP3A4HPGDTYRTDP1 | |
| SCHEMBL29950410 | 0.78 | ALDH1A1 (0.61) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL340086 | 0.78 | NPC1 (0.60) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL67498 | 0.78 | ALDH1A1 (0.61) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL29768449 | 0.78 | SLC6A4 (0.54) | KDM4ECYP1A2SLC6A2SLC6A3 | |
| SCHEMBL1145316 | 0.78 | SLC6A4 (0.54) | KDM4ECYP1A2SLC6A2SLC6A3 | |
| SCHEMBL7771075 | 0.77 | ESR2 (0.57) | NPC1RAB9ACYP3A4MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833821-B1 | SULFAMIDES AS ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-30 | — | — | EP | claimed |
| US-7868012-B2 | Sulfamides as endothelin receptor antagonists for the treatment of cardiovascular diseases | ACTELION PHARMACEUTICALS, LTD. (CH) | 2011-01-11 | — | — | US | claimed |
| US-20080004298-A1 | Sulfamides as Endothelin Receptor Antagonists for the Treatment of Cardiovascular Diseases | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-01-03 | — | — | US | claimed |
| EP-1833821-A2 | SULFAMIDES AS ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2007-09-19 | — | — | EP | claimed |
| WO-2006051502-A2 | SULFAMIDES AS ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-05-18 | — | — | WO | claimed |
| EP-0216714-B1 | PROCESS FOR THE SELECTIVE CHLORINATION OF PHENOLIC COMPOUNDS | RHONE-POULENC CHIMIE (FR) | 1992-05-13 | — | — | EP | claimed |
| EP-0299891-B1 | PROCESS FOR THE SELECTIVE CHLORINATION OF PHENOLIC COMPOUNDS | RHONE-POULENC CHIMIE (FR) | 1991-12-11 | — | — | EP | claimed |
| US-4954662-A | Selective chlorination of ortho-substituted phenols | RHONE-POULENC CHIMIE (FR) | 1990-09-04 | — | — | US | claimed |
| EP-0299891-A1 | Process for the selective chlorination of phenolic compounds | RHONE-POULENC CHIMIE (FR) | 1989-01-18 | — | — | EP | claimed |
| EP-0216714-A2 | Process for the selective chlorination of phenolic compounds | RHONE-POULENC CHIMIE (FR) | 1987-04-01 | — | — | EP | claimed |
| US-12528827-B2 | Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as PAR4 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2026-01-20 | — | — | US | disclosed |
| US-20250361210-A1 | 3,4-DIHYDROQUINOLIN-2(1H)-ONE COMPOUND | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2025-11-27 | — | — | US | disclosed |
| CN-119528804-A | 2- { [2- (Phenoxymethyl) pyridin-5-yl ] oxy } ethanamine derivatives and related compounds as pest control agents, for example, for protecting plants | 发现号收购集团 | 2025-02-28 | — | — | CN | disclosed |
| EP-4512801-A1 | 3,4-DIHYDROQUINOLIN-2(1H)-ONE COMPOUND | Kissei Pharmaceutical Co., Ltd. (JP) | 2025-02-26 | — | — | EP | disclosed |
| CN-119343332-A | 3, 4-Dihydro-quinolin-2 (1H) -one compounds | 橘生药品工业株式会社 | 2025-01-21 | — | — | CN | disclosed |
| US-4029816-A | ANTIHYPERTENSIVE, DIURETIC, SALURETIC | MERCK & CO., INC. (US) | 1977-06-14 | — | — | US | disclosed |
| US-3980659-A | INSECTICIDES, INTERMEDIATES FOR AZO DYES | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1976-09-14 | — | — | US | disclosed |
| US-3959388-A | Preparation of phloroglucinol or its monomethyl ether | ANDENO B.V. (NL) | 1976-05-25 | — | — | US | disclosed |
| US-3954782-A | 2,6-Hydrazino-3-pyridine carboxyamides | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1976-05-04 | — | — | US | disclosed |
| US-3947463-A | Certain 2-amino-nicotinonitrile derivatives | CASSELLA FARBWERKE MAINKUR AG (DT) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004298-A1 | Sulfamides as Endothelin Receptor Antagonists for the Treatment of Cardiovascular Diseases | EDNRA, EDNRB, ECE1 | NPC1 4801/4885RAB9A 3566/4885ALDH1A1 3952/4885 |
| US-20250361210-A1 | 3,4-DIHYDROQUINOLIN-2(1H)-ONE COMPOUND | TSHR, TRHR, GHSR | NPC1 3060/4885RAB9A 247/4885ALDH1A1 1515/4885 |
| US-12528827-B2 | Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as PAR4 inhibitors | F2RL3, F2R, PF4 | NPC1 471/4885RAB9A 695/4885ALDH1A1 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.