Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.62 |
| ▸ | BLM | P54132 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.62 |
| ▸ | SPR | P35270 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | NQO2 | P16083 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800332 | 0.87 | HTR1A (0.59) | MTNR1AMTNR1BKDM4EALDH1A1CYP2D6 | |
| SCHEMBL7015652 | 0.86 | MTNR1A (0.74) | MTNR1AMTNR1BCYP1A2NOTUMBLM | |
| Hydrochloric Acid SCHEMBL9800399 | 0.85 | HTR1A (0.57) | MTNR1AMTNR1BKDM4EALDH1A1CYP2D6 | |
| SCHEMBL9800384 | 0.85 | HTR1D (0.59) | KDM4EALDH1A1CYP2D6NPSR1HTR1A | |
| SCHEMBL9800346 | 0.84 | MPO (0.57) | KDM4ECYP2D6HTR1AMEN1KMT2A | |
| SCHEMBL9800416 | 0.83 | HTR1B (0.54) | KDM4EALDH1A1CYP2D6HPGDNPSR1 | |
| SCHEMBL9800335 | 0.82 | HTR1A (0.61) | CYP1A2CYP3A4CYP2D6MAPTHTR1A | |
| Hydrochloric Acid SCHEMBL9800419 | 0.82 | MPO (0.57) | MTNR1AHTR1AHTR2BMPOHTR1D | |
| SCHEMBL4498391 | 0.82 | MTNR1A (0.72) | MTNR1AMTNR1BCYP1A2NOTUMBLM | |
| SCHEMBL14493805 | 0.82 | MTNR1A (0.72) | MTNR1AMTNR1BCYP1A2NOTUMBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994483-A | 5-substituted-3-aminoalkyl indole derivatives for migraine | GLAXO GROUP LIMITED (GB) | 1991-02-19 | — | — | US | disclosed |