Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316014 | 0.84 | ALDH1A1 (0.57) | KDM4ETSHRALDH1A1ALOX15HPGD | |
| SCHEMBL8660447 | 0.83 | TSHR (0.50) | KDM4ETSHRALDH1A1ALOX15HSD17B10 | |
| SCHEMBL8656659 | 0.83 | GLP1R (0.46) | KDM4ETSHRALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL9315414 | 0.83 | SMN1; SMN2 (0.56) | KDM4ETSHRALDH1A1ALOX15HSD17B10 | |
| SCHEMBL8661094 | 0.83 | ALDH1A1 (0.50) | KDM4ETSHRALDH1A1ALOX15HSD17B10 | |
| SCHEMBL8322828 | 0.83 | KDM4E (0.51) | KDM4ETSHRALDH1A1ALOX15HSD17B10 | |
| SCHEMBL9205477 | 0.82 | TSHR (0.49) | KDM4ETSHRALDH1A1ALOX15HSD17B10 | |
| SCHEMBL8323264 | 0.80 | ALOX15 (0.47) | KDM4ETSHRALDH1A1ALOX15HSD17B10 | |
| SCHEMBL9316182 | 0.80 | KDM4E (0.44) | KDM4ETSHRALDH1A1ALOX15HSD17B10 | |
| SCHEMBL9869495 | 0.80 | CA12 (0.42) | KDM4ETSHRALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220518-B1 | PREPARATION OF SUBSTITUTED AND DISUBSTITUTED PYRIDINE-2,3-DICARBOXYLATE ESTERS | AMERICAN CYANAMID COMPANY (US) | 1991-02-06 | — | — | EP | claimed |
| US-4723011-A | ALPHA-HALO-BETA-KETOESTERS, ALPHA, BETA UNSATURATED KETONE OR ALDEHYDE, AMMONIUM SALT | AMERICAN CYANAMID COMPANY (US) | 1988-02-02 | — | — | US | claimed |
| EP-0220518-A2 | Preparation of substituted and disubstituted pyridine-2,3-dicarboxylate esters | AMERICAN CYANAMID COMPANY (US) | 1987-05-06 | — | — | EP | claimed |