Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38471077 | 0.89 | KDM4E (0.55) | ALDH1A1KDM4EHPGDBRD4L3MBTL1 | |
| SCHEMBL29599305 | 0.89 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDBRD4L3MBTL1 | |
| SCHEMBL2154872 | 0.89 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDBRD4L3MBTL1 | |
| SCHEMBL10391045 | 0.89 | KDM4E (0.55) | ALDH1A1KDM4EHPGDBRD4L3MBTL1 | |
| SCHEMBL10555469 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDL3MBTL1TSHR | |
| SCHEMBL601658 | 0.81 | CYP1A2 (0.54) | ALDH1A1KMT2AMAPTMCL1ALOX15 | |
| SCHEMBL5676787 | 0.81 | KMT2A (0.66) | ALDH1A1KDM4EHPGDBRD4L3MBTL1 | |
| SCHEMBL982547 | 0.80 | NR4A1 (0.54) | ALDH1A1KDM4EHPGDBRD4L3MBTL1 | |
| SCHEMBL31396473 | 0.80 | NR4A1 (0.54) | ALDH1A1KDM4EHPGDBRD4L3MBTL1 | |
| SCHEMBL28027192 | 0.80 | NR4A1 (0.54) | ALDH1A1KDM4EHPGDL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176244-B1 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives | DU PONT (US) | 2016-06-01 | — | — | EP | claimed |
| EP-3150575-B1 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE | DU PONT (US) | 2023-08-09 | — | — | EP | disclosed |
| US-11613516-B2 | Method for preparing 2-amino-n-(2,2,2-trifluoroethyl) acetamide | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2023-03-28 | — | — | US | disclosed |
| US-10745344-B2 | Method for preparing 2-amino-N-(2,2,2-trifluoroethyl) acetamide | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2020-08-18 | — | — | US | disclosed |
| CN-105646215-B | Process for the preparation of 3-trifluoromethyl chalcones | 杜邦公司 | 2020-04-14 | — | — | CN | disclosed |
| US-20190144374-A1 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE | CORTEVA AGRISCIENCE LLC | 2019-05-16 | — | — | US | disclosed |
| US-20190144373-A1 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE | CORTEVA AGRISCIENCE LLC | 2019-05-16 | — | — | US | disclosed |
| US-10202332-B2 | Method for preparing 2-amino-N-(2,2,2-trifluoroethyl) acetamide | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2019-02-12 | — | — | US | disclosed |
| US-10160731-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2018-12-25 | — | — | US | disclosed |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-08-09 | — | — | US | disclosed |
| US-8217180-B2 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-07-10 | — | — | US | disclosed |
| WO-2012047543-A1 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-04-12 | — | — | WO | disclosed |
| CN-101990530-A | Process for the preparation of 3-trifluoromethyl chalcones | DU PONT | 2011-03-23 | — | — | CN | disclosed |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E.I. DU PONT DE NEMOURS AND COMPANY (DE) | 2011-01-13 | — | — | US | disclosed |
| EP-2260016-A2 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E. I. du Pont de Nemours and Company (US) | 2010-12-15 | — | — | EP | disclosed |
| CN-101855215-A | For preparing 5-haloalkyl-4 | DU PONT | 2010-10-06 | — | — | CN | disclosed |
| US-20100249424-A1 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | E.I.DUPONT DE NEMOURS AND COMPANY (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2176244-A2 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | E. I. du Pont de Nemours and Company (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009126668-A2 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009025983-A2 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10160731-B2 | Method for preparing 3-trifluoromethyl chalcones | NR3C2, CYP4A11, RAE1 | ALDH1A1 3337/4885KDM4E 313/4885HPGD 3442/4885 |
| US-10202332-B2 | Method for preparing 2-amino-N-(2,2,2-trifluoroethyl) acetamide | NAAA, SAT1, NAA15 | ALDH1A1 277/4885KDM4E 507/4885HPGD 1259/4885 |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | ALDH1A1 3337/4885KDM4E 313/4885HPGD 3442/4885 |
| US-11613516-B2 | Method for preparing 2-amino-n-(2,2,2-trifluoroethyl) acetamide | NAAA, SAT1, NAA15 | ALDH1A1 277/4885KDM4E 507/4885HPGD 1259/4885 |
| US-20100249424-A1 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | PRDX2, PRXL2A, PRDX1 | ALDH1A1 2265/4885KDM4E 2043/4885HPGD 822/4885 |
| US-10745344-B2 | Method for preparing 2-amino-N-(2,2,2-trifluoroethyl) acetamide | NAAA, SAT1, NAA15 | ALDH1A1 277/4885KDM4E 507/4885HPGD 1259/4885 |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | ALDH1A1 3337/4885KDM4E 313/4885HPGD 3442/4885 |
| US-20190144374-A1 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE | NAAA, SAT1, NAA15 | ALDH1A1 277/4885KDM4E 507/4885HPGD 1259/4885 |
| US-20190144373-A1 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE | NAAA, SAT1, NAA15 | ALDH1A1 277/4885KDM4E 507/4885HPGD 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.