Sugi Predict

Sugi Predict / Compounds / SCHEMBL980491

SCHEMBL980491

SCHEMBL980491

Nc1nnc(-c2sc(Cl)c(Cl)c2Cl)c(N)n1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CYP2D6 P10635 1/20 0.45
▸ MAOA P21397 1/20 0.45
▸ MAPK1 P28482 1/20 0.45
▸ ADRA1A P35348 1/20 0.45
▸ SCN4A P35499 1/20 0.45
▸ BLM P54132 1/20 0.45
▸ PMP22 Q01453 1/20 0.45
▸ PDE3A Q14432 1/20 0.45
▸ SCN5A Q14524 1/20 0.45
▸ SCN9A Q15858 1/20 0.45
▸ SCN2A Q99250 1/20 0.45
▸ SCN3A Q9NY46 1/20 0.45
▸ SCN10A Q9Y5Y9 1/20 0.45
▸ CSNK1A1 P48729 1/20 0.40
▸ CLK4 Q9HAZ1 1/20 0.40
▸ PDPK1 O15530 1/20 0.31
▸ ADORA2A P29274 1/20 0.30
▸ ADORA2B P29275 1/20 0.30
▸ ADORA1 P30542 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL978065 0.72 CYP2D6 (0.48) CYP2D6MAOAMAPK1ADRA1ASCN4A
SCHEMBL976574 0.70 CYP2D6 (0.50) CYP2D6MAOAMAPK1ADRA1ASCN4A
SCHEMBL976587 0.67 CYP2D6 (0.46) CYP2D6MAOAMAPK1ADRA1ASCN4A
SCHEMBL9848562 0.66 SCN9A (0.57) CYP2D6MAOAMAPK1ADRA1ASCN4A
SCHEMBL9848578 0.63 SCN9A (0.54) CYP2D6MAOAMAPK1ADRA1ASCN4A
SCHEMBL7237924 0.63 SCN9A (0.63) CYP2D6MAOAMAPK1ADRA1ASCN4A
SCHEMBL7349151 0.63 CSNK1A1 (0.66) CYP2D6MAOAMAPK1ADRA1ASCN4A
SCHEMBL3929311 0.63 ADORA2A (0.62) CYP2D6MAOAMAPK1ADRA1ASCN4A
Lamotrigine SCHEMBL722975 0.62 SCN9A (1.00) CYP2D6MAOAMAPK1ADRA1ASCN4A
Lamotrigine SCHEMBL35439 0.62 SCN9A (1.00) CYP2D6MAOAMAPK1ADRA1ASCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230167075-A1 INTERLEUKIN INHIBITORS UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US claimed
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US claimed
EP-3002280-B1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIV GREENWICH (GB) 2023-05-24 — — EP claimed
CN-107921046-B Triazine derivatives as interferon-gamma inhibitors 格林威治大学 2022-10-14 — — CN claimed
EP-3307273-B1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIV GREENWICH (GB) 2020-12-09 — — EP claimed
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors UNIVERSITY OF GREENWICH (GB) 2020-03-03 — — US claimed
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2018-06-21 — — US claimed
US-9422253-B2 Cyclic triazo and diazo sodium channel blockers UNIVERSITY OF GREENWICH (GB) 2016-08-23 — — US claimed
EP-3002280-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2016-04-06 — — EP claimed
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2014-06-05 — — US claimed
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US disclosed
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US disclosed
US-20230167075-A1 INTERLEUKIN INHIBITORS UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US disclosed
EP-3002280-B1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIV GREENWICH (GB) 2023-05-24 — — EP disclosed
CN-115737651-A Triazine derivatives as interferon-gamma inhibitors 格林威治大学 2023-03-07 — — CN disclosed
EP-2229371-B1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIV GREENWICH (GB) 2015-12-23 — — EP disclosed
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2014-06-05 — — US disclosed
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2011-01-13 — — US disclosed
EP-2229371-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2010-09-22 — — EP disclosed
WO-2009090431-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2009-07-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS SCN1A, SCN1B, SCN3A CYP2D6 1326/4885MAOA 321/4885MAPK1 3993/4885
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS CACNA1E, SCN2B, SCN3A CYP2D6 3472/4885MAOA 460/4885MAPK1 2697/4885
US-20230167075-A1 INTERLEUKIN INHIBITORS IL2, IL1A, IL1B CYP2D6 276/4885MAOA 1499/4885MAPK1 490/4885
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME IFNG, TNF, IL1A CYP2D6 2190/4885MAOA 3195/4885MAPK1 1954/4885
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors IFNG, IFNAR1, IRF3 CYP2D6 1766/4885MAOA 2704/4885MAPK1 1420/4885
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS IFNG, IFNAR1, IRF3 CYP2D6 1766/4885MAOA 2704/4885MAPK1 1420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.