Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | SCN4A | P35499 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23931345 | 0.79 | SCN2A (0.41) | CYP2D6SCN2ALOXL2HPGDALDH1A1 | |
| SCHEMBL23931343 | 0.77 | DHFR (0.44) | LOXL2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL980491 | 0.72 | CYP2D6 (0.45) | CYP2D6MAOAMAPK1ADRA1ASCN4A | |
| SCHEMBL15931657 | 0.71 | MAPT (0.41) | MAPK1PMP22LOXL2HPGDALDH1A1 | |
| SCHEMBL30413445 | 0.69 | CSNK1A1 (0.55) | CYP2D6MAOAMAPK1ADRA1ASCN4A | |
| SCHEMBL979602 | 0.69 | CSNK1A1 (0.55) | CYP2D6MAOAMAPK1ADRA1ASCN4A | |
| SCHEMBL978238 | 0.69 | APP (0.50) | CYP2D6MAOAMAPK1ADRA1ASCN4A | |
| SCHEMBL7666598 | 0.68 | MCL1 (0.52) | BLMLOXL2HPGDALDH1A1MEN1 | |
| SCHEMBL10811842 | 0.67 | SCN9A (0.75) | CYP2D6MAOAMAPK1ADRA1ASCN4A | |
| SCHEMBL14315167 | 0.67 | LOXL2 (0.59) | LOXL2HPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230165869-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | UNIVERSITY OF GREENWICH (GB) | 2023-06-01 | — | — | US | claimed |
| EP-3002280-B1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIV GREENWICH (GB) | 2023-05-24 | — | — | EP | claimed |
| EP-4138838-A1 | INTERLEUKIN INHIBITORS | University of Greenwich (GB) | 2023-03-01 | — | — | EP | claimed |
| EP-4138839-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | University of Greenwich (GB) | 2023-03-01 | — | — | EP | claimed |
| WO-2021214495-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | UNIVERSITY OF GREENWICH (GB) | 2021-10-28 | — | — | WO | claimed |
| WO-2021214494-A1 | INTERLEUKIN INHIBITORS | UNIVERSITY OF GREENWICH (GB) | 2021-10-28 | — | — | WO | claimed |
| US-9422253-B2 | Cyclic triazo and diazo sodium channel blockers | UNIVERSITY OF GREENWICH (GB) | 2016-08-23 | — | — | US | claimed |
| US-20140155403-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2014-06-05 | — | — | US | claimed |
| EP-3002280-B1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIV GREENWICH (GB) | 2023-05-24 | — | — | EP | disclosed |
| EP-4138838-A1 | INTERLEUKIN INHIBITORS | University of Greenwich (GB) | 2023-03-01 | — | — | EP | disclosed |
| EP-4138839-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | University of Greenwich (GB) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021214495-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | UNIVERSITY OF GREENWICH (GB) | 2021-10-28 | — | — | WO | disclosed |
| WO-2021214494-A1 | INTERLEUKIN INHIBITORS | UNIVERSITY OF GREENWICH (GB) | 2021-10-28 | — | — | WO | disclosed |
| US-9862691-B2 | Cyclic triazo and diazo sodium channel blockers | UNIVERSITY OF GREENWICH (GB) | 2018-01-09 | — | — | US | disclosed |
| US-9422253-B2 | Cyclic triazo and diazo sodium channel blockers | UNIVERSITY OF GREENWICH (GB) | 2016-08-23 | — | — | US | disclosed |
| EP-3002280-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | University of Greenwich (GB) | 2016-04-06 | — | — | EP | disclosed |
| US-20140155403-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2014-06-05 | — | — | US | disclosed |
| US-20110009413-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2011-01-13 | — | — | US | disclosed |
| EP-2229371-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | University of Greenwich (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009090431-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155403-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | SCN1A, SCN1B, SCN3A | CYP2D6 1326/4885MAOA 321/4885MAPK1 3993/4885 |
| US-20110009413-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | CACNA1E, SCN2B, SCN3A | CYP2D6 3472/4885MAOA 460/4885MAPK1 2697/4885 |
| US-20230165869-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | IFNG, TNF, IL1A | CYP2D6 2190/4885MAOA 3195/4885MAPK1 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.