Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.53 |
| ▸ | DRD3 | P35462 | 10/20 | 0.53 |
| ▸ | HTR1A | P08908 | 9/20 | 0.53 |
| ▸ | HTR2A | P28223 | 9/20 | 0.53 |
| ▸ | DRD1 | P21728 | 5/20 | 0.53 |
| ▸ | DRD5 | P21918 | 5/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 4/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9809300 | 0.85 | DRD2 (0.53) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL9809305 | 0.81 | USP2 (0.59) | DRD2DRD3HTR1AHTR2ADRD1 | |
| Hydrochloric Acid SCHEMBL9809253 | 0.80 | ALDH1A1 (0.58) | DRD2DRD3HTR1AHTR2ADRD1 | |
| Hydrochloric Acid SCHEMBL10938367 | 0.79 | DRD2 (0.50) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL9809303 | 0.78 | MAPK1 (0.65) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL10507398 | 0.78 | SIGMAR1 (0.55) | DRD2DRD3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9809264 | 0.77 | MEN1 (0.65) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL9809302 | 0.77 | HRH2 (0.47) | DRD2HRH1 | |
| SCHEMBL10506915 | 0.77 | TSHR (0.47) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL10939271 | 0.76 | MAPT (0.49) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0211928-B1 | PIPERAZINECARBOXAMIDES HAVING A PHENOXYALKYL OR THIOPHENOXYALKYL SIDE CHAIN | AB LEO (SE) | 1991-05-02 | — | — | EP | disclosed |