Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | TACR2 | P21452 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754529 | 1.00 | RARB (0.55) | RARBHSD17B10TSHRNISCHALDH1A1 | |
| SCHEMBL981933 | 0.94 | HSD17B10 (0.61) | RARBHSD17B10TSHRALDH1A1MEN1 | |
| SCHEMBL28518716 | 0.92 | HSD17B10 (0.64) | RARBHSD17B10TSHRALDH1A1MEN1 | |
| SCHEMBL983507 | 0.92 | HSD17B10 (0.64) | RARBHSD17B10TSHRALDH1A1MEN1 | |
| SCHEMBL5544425 | 0.92 | HSD17B10 (0.64) | RARBHSD17B10TSHRALDH1A1MEN1 | |
| SCHEMBL3090093 | 0.92 | HSD17B10 (0.64) | RARBHSD17B10TSHRALDH1A1MEN1 | |
| SCHEMBL5542220 | 0.92 | HSD17B10 (0.64) | RARBHSD17B10TSHRALDH1A1MEN1 | |
| SCHEMBL17022435 | 0.92 | HSD17B10 (0.64) | RARBHSD17B10TSHRALDH1A1MEN1 | |
| SCHEMBL533509 | 0.87 | MCL1 (0.47) | RARBHSD17B10TSHRNISCHALDH1A1 | |
| SCHEMBL17930 | 0.87 | CA2 (0.48) | RARBHSD17B10TSHRNISCHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115043810-B | Method for preparing chiral hydrocarbon bond oxidation product by non-metal catalyzed asymmetric hydrocarbon bond oxidation | 浙江大学 | 2024-04-19 | — | — | CN | claimed |
| CN-115043810-A | Method for preparing chiral carbon-hydrogen bond oxidation product by non-metal catalyzed asymmetric carbon-hydrogen bond oxidation | 浙江大学 | 2022-09-13 | — | — | CN | claimed |
| US-8546441-B2 | PDK-1/AKT signaling inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-10-01 | — | — | US | claimed |
| US-8541460-B2 | Phosphoinositide-dependent kinase-1 (PDK-1) inhibitors; for the treatment and prevention of cancer in humans; 4-[5-(2-Phenanthracenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenecarboxamide | THE OHIO STATE UNIVERSITY (US) | 2013-09-24 | — | — | US | claimed |
| EP-1696907-B1 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2013-04-17 | — | — | EP | claimed |
| US-8080574-B2 | PDK-1/Akt signaling inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-12-20 | — | — | US | claimed |
| JP-4745971-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| EP-1720872-B1 | ARYL AND HETEROARYL-PIPERIDINECARBOXYLATE DERIVATIVES, THE PREPARATION AND THE USE THEREOF IN THE FORM OF FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2011-04-20 | — | — | EP | claimed |
| US-20110015242-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-01-20 | — | — | US | claimed |
| CN-1889949-B | PDK-1/Akt signaling inhibitors | UNIV OHIO STATE RES FOUND | 2010-06-16 | — | — | CN | claimed |
| EP-1499597-A4 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | UNIV OHIO STATE RES FOUND (US) | 2006-01-25 | — | — | EP | claimed |
| WO-2005044130-A9 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2005-09-15 | — | — | WO | claimed |
| WO-2005044130-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-05-19 | — | — | WO | claimed |
| CN-1582287-A | Thiophenylthiopyrane dioxides as MMP or TNF-alpha inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-02-16 | — | — | CN | claimed |
| EP-1499597-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-01-26 | — | — | EP | claimed |
| US-20040266826-A1 | Thiophenylthiopyrane dioxides as mmp or tnf-alpha inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-30 | — | — | US | claimed |
| EP-1423386-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-02 | — | — | EP | claimed |
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | NIH - DEITR | 2003-12-25 | — | — | US | claimed |
| WO-2003086287-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2003-10-23 | — | — | WO | claimed |
| WO-2003022842-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015242-A1 | PDK-1/AKT SIGNALING INHIBITORS | PDPK1, TNNI3K, MAP3K1 | RARB 4688/4885HSD17B10 3156/4885TSHR 2128/4885 |
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MCL1, BRDT, BAD | RARB 485/4885HSD17B10 1675/4885TSHR 3239/4885 |
| US-20040266826-A1 | Thiophenylthiopyrane dioxides as mmp or tnf-alpha inhibitors | TNF, MMP9, MMP1 | RARB 3160/4885HSD17B10 1838/4885TSHR 2444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.