Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.42 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9788696 | 0.84 | ALDH1A1 (0.53) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 | |
| SCHEMBL9328124 | 0.80 | ALOX15 (0.57) | ALDH1A1ALOX15LMNAHSD17B10CYP2C9 | |
| SCHEMBL9441416 | 0.79 | ALDH1A1 (0.48) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 | |
| SCHEMBL316680 | 0.77 | ALDH1A1 (0.59) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 | |
| SCHEMBL9340912 | 0.77 | ALDH1A1 (0.59) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 | |
| SCHEMBL7523538 | 0.77 | ALDH1A1 (0.46) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 | |
| SCHEMBL11560736 | 0.77 | ALDH1A1 (0.46) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 | |
| SCHEMBL9680940 | 0.77 | ALDH1A1 (0.46) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 | |
| SCHEMBL20680463 | 0.76 | ALDH1A1 (0.57) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 | |
| SCHEMBL10626842 | 0.76 | ALOX15 (0.61) | ALDH1A1ALOX15LMNAHSD17B10NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5002967-A | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1991-03-26 | — | — | US | disclosed |