Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11143695 | 0.81 | MEN1 (0.59) | MEN1LMNAKMT2ACA2 | |
| SCHEMBL1046637 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL4697105 | 0.75 | MAPT (0.40) | MEN1LMNAKMT2AALDH1A1MAPT | |
| SCHEMBL1780393 | 0.72 | KDM4E (0.38) | ALDH1A1CA2 | |
| Deanol SCHEMBL1780396 | 0.71 | LMNA (0.35) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL5988271 | 0.70 | LMNA (0.67) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL1508805 | 0.70 | LMNA (0.67) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL4939766 | 0.70 | LMNA (0.67) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL2859906 | 0.70 | MEN1 (0.50) | MEN1LMNAKMT2ACA2 | |
| Tromethamine SCHEMBL7510306 | 0.69 | MEN1 (0.77) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110005038-A1 | BUTTON MADE OF BIOMASS MATERIAL AND METHOD FOR PRODUCING THE SAME | TEIJIN LIMITED (JP) | 2011-01-13 | — | — | US | disclosed |