Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL21647312 | 0.82 | MEN1 (0.53) | MEN1LMNAKMT2ACA1CA2 | |
| Tromethamine SCHEMBL11143695 | 0.81 | MEN1 (0.59) | MEN1LMNAKMT2ACA1CA2 | |
| Tromethamine SCHEMBL1508805 | 0.75 | LMNA (0.67) | MEN1LMNAKMT2ACA1CA2 | |
| Tromethamine SCHEMBL5988271 | 0.75 | LMNA (0.67) | MEN1LMNAKMT2ACA1CA2 | |
| Tromethamine SCHEMBL4939766 | 0.75 | LMNA (0.67) | MEN1LMNAKMT2ACA1CA2 | |
| SCHEMBL245997 | 0.74 | — | — | |
| SCHEMBL1863468 | 0.74 | — | — | |
| Tromethamine SCHEMBL6064575 | 0.74 | LMNA (0.56) | MEN1LMNAKMT2ACA1CA2 | |
| Tromethamine SCHEMBL7193959 | 0.71 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL28216031 | 0.71 | MEN1 (0.83) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998351-B1 | USE OF TRIS (TRIFLUORO METHYLSULFONYL) METHANE, IN ADDITION TO ALKALINE METAL SALTS AND ALKALINE-EARTH METAL SALTS THEREOF AS CATALYSTS DURING C-C BONDING SYNTHESES AND THE NOVEL Mg SALT OF TRIS (TRIFLUORO METHYLSULFONYL) METHANE | MERCK PATENT GMBH (DE) | 2001-05-30 | — | — | EP | claimed |
| EP-3374461-A1 | BARRIER ADHESIVE MASS WITH POLYMER GETTER MATERIAL | tesa SE (DE) | 2018-09-19 | — | — | EP | disclosed |
| US-7713658-B2 | Material for electrolytic solutions and use thereof | NIPPON SHOKUBAI CO., LTD. (JP) | 2010-05-11 | — | — | US | disclosed |
| US-7521006-B2 | Diimmonium compound and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2009-04-21 | — | — | US | disclosed |
| US-20080067478-A1 | Quaternary salt of N,N,N',N'-tetrakis(p-aminophenyl)phenylene diimmonium compound; stability; heat and light resistance; near-infrared aborbing filters, optical recording media and filters, plasma display panels | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2008-03-20 | — | — | US | disclosed |
| US-6433227-B1 | REACTING ELECTROPHILIC AND NUCLEOPHILIC COMPOUND | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080067478-A1 | Quaternary salt of N,N,N',N'-tetrakis(p-aminophenyl)phenylene diimmonium compound; stability; heat and light resistance; near-infrared aborbing filters, optical recording media and filters, plasma display panels | ATP1B1, RER1, PNISR | MEN1 1463/4885LMNA 1924/4885KMT2A 3139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.