Sugi Predict

Sugi Predict / Compounds / SCHEMBL981519

SCHEMBL981519

SCHEMBL981519

O=C(O)c1cc(O)nc(-c2ccccc2)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGDS O60760 1/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ NTSR1 P30989 1/20 0.46
▸ ALOX15 P16050 3/20 0.45
▸ TSHR P16473 2/20 0.45
▸ HIF1A Q16665 1/20 0.45
▸ ALDH1A1 P00352 4/20 0.44
▸ MCL1 Q07820 2/20 0.44
▸ RPA1 P27694 1/20 0.44
▸ KMO O15229 1/20 0.43
▸ LMNA P02545 1/20 0.42
▸ NAPRT Q6XQN6 1/20 0.42
▸ P4HTM Q9NXG6 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ ACMSD Q8TDX5 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ HPGD P15428 2/20 0.42
▸ HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4265697 0.83 KMO (0.58) MEN1KMT2ANTSR1ALDH1A1MCL1
SCHEMBL18760499 0.82 MEN1 (0.57) MEN1KMT2ANTSR1ALOX15TSHR
SCHEMBL3165362 0.82 MEN1 (0.57) MEN1KMT2ANTSR1ALOX15TSHR
SCHEMBL523744 0.80 LMNA (0.56) HPGDSMEN1KMT2AALOX15TSHR
SCHEMBL2577413 0.80 LMNA (0.61) MEN1KMT2AALOX15TSHRHIF1A
SCHEMBL19286913 0.79 SCN9A (0.49) MEN1KMT2ANTSR1ALDH1A1MCL1
SCHEMBL1560671 0.78 L3MBTL1 (0.53) KMT2AALOX15ALDH1A1LMNANAPRT
SCHEMBL2118725 0.78 MEN1 (0.59) MEN1KMT2ANTSR1ALOX15TSHR
SCHEMBL2581896 0.77 LMNA (0.55) MEN1KMT2ALMNAKDM4EHPGD
SCHEMBL6397903 0.77 LMNA (0.57) MEN1KMT2ATSHRALDH1A1MCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107698517-A One kind 2（4 fluorophenyls）The preparation method of pyrimidine derivatives 湖南华腾制药有限公司 2018-02-16 — — CN disclosed
CN-106854181-A A kind of preparation method of pyrimidine compound 湖南华腾制药有限公司 2017-06-16 — — CN disclosed
US-20110039847-A1 AMIDE DERIVATIVES AS SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC (US) 2011-02-17 — — US disclosed
US-20110039847-A1 AMIDE DERIVATIVES AS SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC (US) 2011-02-17 — — US disclosed
US-20110039847-A1 AMIDE DERIVATIVES AS SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC (US) 2011-02-17 — — US disclosed
US-20110009381-A1 SOLUBILIZED THIAZOLOPYRIDINES SIRTIS PHARMACEUTICALS, INC. (US) 2011-01-13 — — US disclosed
US-20110009381-A1 SOLUBILIZED THIAZOLOPYRIDINES SIRTIS PHARMACEUTICALS, INC. (US) 2011-01-13 — — US disclosed
US-20110009381-A1 SOLUBILIZED THIAZOLOPYRIDINES SIRTIS PHARMACEUTICALS, INC. (US) 2011-01-13 — — US disclosed
CN-101910184-A Solubility thiazole and pyridine SIRTRIS PHARMACEUTICALS INC 2010-12-08 — — CN disclosed
EP-2217606-A1 SOLUBILIZED THIAZOLOPYRIDINES Sirtris Pharmaceuticals, Inc. (US) 2010-08-18 — — EP disclosed
US-4942225-A Preparation of diazo and azo compounds using azidoformamidium salts BAYER AKTIENGESELLSCHAFT (DE) 1990-07-17 — — US disclosed
EP-0297397-A2 Preparation of diazo and azo compounds BAYER AG (DE) 1989-01-04 — — EP disclosed
US-4628082-A Derivatives of azobarbituric acid or salts or complexes thereof BAYER AKTIENGESELLSCHAFT (DE) 1986-12-09 — — US disclosed
US-4622391-A ORGANIC PIGMENTS BAYER AKTIENGESELLSCHAFT (DE) 1986-11-11 — — US disclosed
EP-0093306-B1 METHODS FOR THE PREPARATION OF AZO COMPOUNDS, AND AZO COMPOUNDS BAYER AG (DE) 1986-09-24 — — EP disclosed
EP-0074515-B1 AZO DERIVATIVES OF BARBITURIC ACID, THEIR SOLID SOLUTIONS, INSERTION COMPOUNDS AND INTERCALATION COMPOUNDS BAYER AG (DE) 1986-08-20 — — EP disclosed
EP-0073463-B1 INSERTION COMPOUNDS, INTERCALATION COMPOUNDS AND SOLID SOLUTIONS OF COLOURED METALLIC ORGANIC DERIVATIVES BAYER AG (DE) 1985-10-23 — — EP disclosed
EP-0093306-A1 Methods for the preparation of azo compounds, and azo compounds BAYER AG (DE) 1983-11-09 — — EP disclosed
EP-0074515-A1 Azo derivatives of barbituric acid, their solid solutions, insertion compounds and intercalation compounds BAYER AG (DE) 1983-03-23 — — EP disclosed
EP-0073463-A1 Insertion compounds, intercalation compounds and solid solutions of coloured metallic organic derivatives BAYER AG (DE) 1983-03-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009381-A1 SOLUBILIZED THIAZOLOPYRIDINES SIRT3, SIRT1, SIRT2 HPGDS 913/4885MEN1 3822/4885KMT2A 2694/4885
US-20110039847-A1 AMIDE DERIVATIVES AS SIRTUIN MODULATORS SIRT1, SIRT3, SIRT2 HPGDS 948/4885MEN1 4415/4885KMT2A 1123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.