Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 6/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.33 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.33 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27914204 | 0.98 | AHR (0.34) | AHRALDH1A1TSHRKIF11CES2 | |
| SCHEMBL15063925 | 0.83 | KIF11 (0.48) | AHRKIF11 | |
| SCHEMBL193576 | 0.82 | — | — | |
| SCHEMBL596825 | 0.78 | TSHR (0.42) | TSHR | |
| SCHEMBL622951 | 0.77 | PDE2A (0.42) | PDE2A | |
| SCHEMBL11798351 | 0.76 | TSHR (0.39) | ALDH1A1TSHRKIF11 | |
| SCHEMBL60519 | 0.73 | ALDH1A1 (0.36) | ALDH1A1TSHRKIF11CES2CES1 | |
| SCHEMBL221733 | 0.73 | ALDH1A1 (0.36) | AHRALDH1A1TSHRKIF11CES2 | |
| SCHEMBL457115 | 0.72 | MAOB (0.45) | ALDH1A1TSHRKIF11KDM4ENOTUM | |
| SCHEMBL192799 | 0.71 | ALDH1A1 (0.35) | ALDH1A1TSHRKIF11CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1386 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11987588-B2 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2024-05-21 | — | — | US | claimed |
| EP-3750894-B1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2024-04-03 | — | — | EP | claimed |
| EP-3590941-B1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXANE-QUINAZOLINE AND -LINKED DIOXANE-QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-11-22 | — | — | EP | claimed |
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | claimed |
| EP-3720858-B1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2023-06-07 | — | — | EP | claimed |
| EP-3750893-B1 | DIOXAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-04-19 | — | — | EP | claimed |
| US-20220396579-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2022-12-15 | — | — | US | claimed |
| CN-111196773-B | 2- (3-oxo-2-pentylcyclopentyl) acetamide derivative and application thereof | 沈阳化工研究院有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-106659714-B | Imidazole and thiazole compositions for altering biological signaling | 俄亥俄大学 | 2021-06-08 | — | — | CN | claimed |
| US-10980809-B2 | Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2021-04-20 | — | — | US | claimed |
| EP-0201203-A2 | Method of treatment of plants with aniline derivatives | MAY & BAKER LIMITED (GB) | 1986-11-12 | — | — | EP | claimed |
| EP-0183174-A2 | Substituted phenoxy urea, processes for its preparation and herbicide containing it as active ingredient | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1986-06-04 | — | — | EP | claimed |
| US-4378357-A | FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1983-03-29 | — | — | US | claimed |
| US-4283334-A | DIURETICS | AMERICAN CYANAMID COMPANY (US) | 1981-08-11 | — | — | US | claimed |
| US-4264605-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1981-04-28 | — | — | US | claimed |
| US-4198205-A | SULFONIC ACID-FREE DISPERSE DYES | BASF AKTIENGESELLSCHAFT (DE) | 1980-04-15 | — | — | US | claimed |
| EP-0008881-A1 | 1-Benzoyl-3-pyridinyl ureas, their use as insecticides, their preparation and formulations containing them | ELI LILLY AND COMPANY (US) | 1980-03-19 | — | — | EP | claimed |
| US-4179466-A | Phthalic dianilides | MONSANTO COMPANY (US) | 1979-12-18 | — | — | US | claimed |
| US-4146386-A | Phthalic dianilides and their use as plant growth regulators | MONSANTO COMPANY (US) | 1979-03-27 | — | — | US | claimed |
| US-3973010-A | Insecticidal and acaricidal composition and method with triazolyl phosphoric esters acid | CIBA-GEIGY CORPORATION (US) | 1976-08-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | CSNK1A1, CSNK1D, CSNK1G1 | AHR 4371/4885ALDH1A1 1318/4885TSHR 4243/4885 |
| US-11987588-B2 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto | ADRB3, ADRB1, ADRB2 | AHR 998/4885ALDH1A1 700/4885TSHR 639/4885 |
| US-10980809-B2 | Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof | BRAF, RAF1, ARAF | AHR 91/4885ALDH1A1 510/4885TSHR 1188/4885 |
| US-20220396579-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ADRB3, ADRB1, ADRB2 | AHR 1048/4885ALDH1A1 682/4885TSHR 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.