Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390027 | 0.77 | HTR2A (0.38) | MAOAMAOBHTR2ACYP2D6MEN1 | |
| SCHEMBL29433715 | 0.77 | HTR2A (0.38) | MAOAMAOBHTR2ACYP2D6MEN1 | |
| SCHEMBL2587972 | 0.66 | MAOA (0.46) | MAOAMAOBMEN1GAAKMT2A | |
| SCHEMBL27731579 | 0.66 | MAOA (0.33) | MAOAMAOB | |
| SCHEMBL14721861 | 0.63 | PRCP (0.37) | HTR2AGAA | |
| SCHEMBL28445883 | 0.62 | MAOA (0.33) | MAOAMAOBHTR2ACYP2D6MEN1 | |
| SCHEMBL7790709 | 0.62 | MAOA (0.33) | MAOAMAOBHTR2ACYP2D6MEN1 | |
| SCHEMBL31099344 | 0.62 | HTR2A (0.50) | MAOAMAOBHTR2ACYP2D6MEN1 | |
| SCHEMBL1276091 | 0.62 | HTR2A (0.50) | MAOAMAOBHTR2ACYP2D6MEN1 | |
| SCHEMBL3628239 | 0.60 | MAOA (0.60) | MAOAMAOBHTR2ACYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173899-B1 | 2,3-DIHYDROBENZOFURAN-5-SULFONAMIDE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| US-4659709-A | LESS ADVERSE SIDE-EFFECTS | SHIONOGI & CO. (JP) | 1987-04-21 | — | — | US | disclosed |
| EP-0173899-A2 | 2,3-Dihydrobenzofuran-5-sulfonamide derivatives | SHIONOGI & CO., LTD. (JP) | 1986-03-12 | — | — | EP | disclosed |