Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 4/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10943673 | 0.81 | HSD17B10 (0.44) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL4176549 | 0.77 | TSHR (0.42) | CYP3A4PNMTTAAR1TSHRIDO1 | |
| SCHEMBL97464 | 0.76 | PNMT (0.54) | ALDH1A1PNMTTAAR1TSHRIDO1 | |
| SCHEMBL2869225 | 0.75 | KDM4E (0.42) | ALDH1A1CYP3A4HPGDHSD17B10CRHBP | |
| SCHEMBL9818210 | 0.73 | ALDH1A1 (0.33) | ALDH1A1CYP3A4HPGDHSD17B10CRHBP | |
| SCHEMBL8943857 | 0.72 | ALDH1A1 (0.46) | ALDH1A1CYP3A4HPGDPNMTTAAR1 | |
| SCHEMBL1529004 | 0.72 | CA2 (0.56) | CYP3A4HSD17B10TSHR | |
| SCHEMBL5253367 | 0.70 | ALDH1A1 (0.45) | ALDH1A1CYP3A4HPGDHSD17B10CRHBP | |
| SCHEMBL11199932 | 0.70 | IGF1R (0.33) | ALDH1A1 | |
| SCHEMBL5544644 | 0.70 | CYP3A4 (0.37) | ALDH1A1CYP3A4HPGDHSD17B10CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126635-B1 | NOVEL OXINDOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| US-4694017-A | 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-09-15 | — | — | US | disclosed |
| EP-0126635-A2 | Novel oxindole derivative | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-28 | — | — | EP | disclosed |