Oxfendazole

Oxfendazole

SCHEMBL9818561

COC(=O)Nc1nc2ccc([S+]([O-])c3ccccc3)cc2[nH]1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 9/20 0.64
CYP1A2 P05177 6/20 0.64
HIF1A Q16665 5/20 0.64
ALDH1A1 P00352 3/20 0.64
KDR P35968 3/20 0.64
ABL1 P00519 2/20 0.64
CYP2C9 P11712 2/20 0.64
HTT P42858 2/20 0.64
ABCC4 O15439 1/20 0.64
USP2 O75604 1/20 0.64
MEN1 O00255 2/20 0.63
KMT2A Q03164 2/20 0.63
NR1I2 O75469 1/20 0.63
MAPK14 Q16539 1/20 0.63
HPGD P15428 3/20 0.61
ADORA2A P29274 2/20 0.61
KDM4E B2RXH2 1/20 0.61
CYP3A4 P08684 1/20 0.61
HSD17B10 Q99714 1/20 0.61
TEK Q02763 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxfendazole SCHEMBL29351297 1.00 LMNA (0.64) LMNACYP1A2HIF1AALDH1A1KDR
Oxfendazole SCHEMBL29409244 0.91 LMNA (0.55) LMNACYP1A2HIF1AALDH1A1KDR
Oxfendazole SCHEMBL44121 0.91 LMNA (0.55) LMNACYP1A2HIF1AALDH1A1KDR
Oxfendazole SCHEMBL27586080 0.89 LMNA (0.54) LMNACYP1A2HIF1AALDH1A1KDR
SCHEMBL24209251 0.89 LMNA (0.51) LMNACYP1A2HIF1AALDH1A1KDR
SCHEMBL11219230 0.88 ABL1 (0.47) LMNACYP1A2HIF1AALDH1A1KDR
SCHEMBL11258288 0.86 LMNA (0.58) LMNACYP1A2HIF1AALDH1A1KDR
Oxfendazole SCHEMBL28641495 0.85 LMNA (0.50) LMNACYP1A2HIF1AALDH1A1KDR
SCHEMBL11663912 0.85 LMNA (0.54) LMNACYP1A2HIF1AALDH1A1KDR
SCHEMBL20657154 0.83 LMNA (0.60) LMNACYP1A2HIF1AALDH1A1KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190015423-A1 REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2019-01-17 US claimed
EP-0059074-B1 ANTHELMINTIC COMPOSITION AND THE USE THEREOF SANKYO COMPANY LIMITED (JP) 1984-10-10 EP claimed
US-4468390-A Anthelmintic composition and the use thereof SANKYO COMPANY, LIMITED (JP) 1984-08-28 US claimed
EP-0059074-A1 Anthelmintic composition and the use thereof SANKYO COMPANY LIMITED (JP) 1982-09-01 EP claimed
US-20250268819-A1 DEVICES AND METHODS FOR DELIVERING METHANE INHIBITING COMPOUNDS TO ANIMALS RUMINANT BIOTECH CORP LTD (NZ) 2025-08-28 US disclosed
EP-4580602-A2 DEVICES AND METHODS FOR DELIVERING METHANE INHIBITING COMPOUNDS TO ANIMALS RUMINANT BIOTECH CORP LIMITED (NZ) 2025-07-09 EP disclosed
US-20240398702-A1 DEVICES AND METHODS FOR DELIVERING METHANE INHIBITING COMPOUNDS TO ANIMALS Ruminant Biotech Corp Limited (NZ) 2024-12-05 US disclosed
US-12115248-B2 Devices and methods for delivering methane inhibiting compounds to animals Ruminant Biotech Corp Limited (NZ) 2024-10-15 US disclosed
WO-2024096749-A2 DEVICES AND METHODS FOR DELIVERING METHANE INHIBITING COMPOUNDS TO ANIMALS Ruminant Biotech Corp Limited (NZ) 2024-05-10 WO disclosed
US-20240139103-A1 Devices and Methods for Delivering Methane Inhibiting Compounds to Animals Ruminant Biotech Corp Limited (NZ) 2024-05-02 US disclosed
CN-117825570-A Method for simultaneously detecting imidazole drugs and metabolic residues thereof in food 重庆市计量质量检测研究院 2024-04-05 CN disclosed
CN-115927390-A Cymbidium sinense organ development gene CsPI1 and coding protein and application thereof 华南农业大学 2023-04-07 CN disclosed
EP-0224257-A1 Stabilized benzimidazole derivatives SYNTEX (U.S.A.) INC. (US) 1987-06-03 EP disclosed
US-4642230-A LIQUID IMPERMEABLE CASING SURROUNDING BIOLOGICALLY ACTIVE CORE; EXPOSURED ON AS LEAST ONE END CASTEX PRODUCTS LIMITED (GB) 1987-02-10 US disclosed
EP-0164927-A2 Release devices CASTEX PRODUCTS LIMITED (GB) 1985-12-18 EP disclosed
EP-0059074-B1 ANTHELMINTIC COMPOSITION AND THE USE THEREOF SANKYO COMPANY LIMITED (JP) 1984-10-10 EP disclosed
US-4468390-A Anthelmintic composition and the use thereof SANKYO COMPANY, LIMITED (JP) 1984-08-28 US disclosed
EP-0059074-A1 Anthelmintic composition and the use thereof SANKYO COMPANY LIMITED (JP) 1982-09-01 EP disclosed
US-4321393-A Method for preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles SMITHKLINE CORPORATION (US) 1982-03-23 US disclosed
US-4285878-A N-Phenyl-N'-cyano-O-phenylisoureas SMITHKLINE CORPORATION (US) 1981-08-25 US disclosed