Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819345 | 0.94 | MAPT (0.54) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL9819070 | 0.92 | KCNMA1 (0.50) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL9818807 | 0.91 | APP (0.52) | MAPTMEN1KMT2AAPPRAB9A | |
| SCHEMBL9818887 | 0.85 | IDO1 (0.47) | MAPTMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL9819083 | 0.84 | TRPV1 (0.54) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL9819360 | 0.83 | RAPGEF3 (0.43) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL9819414 | 0.82 | LMNA (0.45) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL9819084 | 0.80 | MAPT (0.51) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL9818871 | 0.79 | AR (0.59) | MAPTHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL9819219 | 0.79 | AR (0.48) | MAPTMEN1KMT2AHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034410-A | Nitrile and oxo containing amides or thioamides | SYNTEX (U.S.A.) INC. (US) | 1991-07-23 | — | — | US | disclosed |