Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.56 |
| ▸ | REN | P00797 | 6/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NMT2 | O60551 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819777 | 1.00 | METAP2 (0.56) | METAP2RENBCHECHRNB2CHRNB4 | |
| SCHEMBL9819802 | 0.84 | METAP2 (0.40) | METAP2REN | |
| SCHEMBL3564135 | 0.83 | REN (0.48) | METAP2RENBCHECHRNB2CHRNB4 | |
| SCHEMBL9819691 | 0.80 | METAP2 (0.38) | METAP2REN | |
| SCHEMBL9819688 | 0.80 | METAP2 (0.38) | METAP2REN | |
| SCHEMBL3565758 | 0.74 | REN (0.39) | METAP2RENBCHECHRNB2CHRNB4 | |
| SCHEMBL3565755 | 0.74 | REN (0.39) | METAP2RENBCHECHRNB2CHRNB4 | |
| SCHEMBL7724633 | 0.72 | USP2 (0.39) | — | |
| SCHEMBL7355197 | 0.72 | METAP2 (1.00) | METAP2RENCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9684341 | 0.71 | REN (1.00) | METAP2RENBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |