Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.40 |
| ▸ | METAP1 | P53582 | 5/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819691 | 0.86 | METAP2 (0.38) | METAP2METAP1RENCTSKCTSS | |
| SCHEMBL9819688 | 0.86 | METAP2 (0.38) | METAP2METAP1RENCTSKCTSS | |
| SCHEMBL9819777 | 0.84 | METAP2 (0.56) | METAP2REN | |
| SCHEMBL9819783 | 0.84 | METAP2 (0.56) | METAP2REN | |
| SCHEMBL7441667 | 0.83 | REN (0.38) | METAP2METAP1RENCTSKCTSS | |
| SCHEMBL3564135 | 0.73 | REN (0.48) | METAP2RENCTSK | |
| SCHEMBL9514512 | 0.72 | METAP2 (0.62) | METAP2METAP1REN | |
| SCHEMBL9514503 | 0.72 | METAP2 (0.62) | METAP2METAP1REN | |
| SCHEMBL9514498 | 0.72 | METAP2 (0.62) | METAP2METAP1REN | |
| SCHEMBL7268415 | 0.72 | CTSK (0.37) | METAP2RENCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |