Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868166 | 0.85 | KEAP1 (0.33) | KEAP1NFE2L2PARP1KDM4ESMN1; SMN2 | |
| SCHEMBL9868204 | 0.83 | PARP1 (0.36) | KEAP1NFE2L2PARP1KDM4ESMN1; SMN2 | |
| SCHEMBL9822823 | 0.83 | PNMT (0.35) | KEAP1NFE2L2PARP1KDM4ESMN1; SMN2 | |
| SCHEMBL10964226 | 0.83 | MEN1 (0.45) | KEAP1NFE2L2PARP1KDM4ESMN1; SMN2 | |
| SCHEMBL10369313 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9822911 | 0.81 | PGR (0.34) | KEAP1NFE2L2BRD4KDM4EALDH1A1 | |
| SCHEMBL11270751 | 0.79 | ALDH1A1 (0.40) | KDM4ESMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL7395597 | 0.77 | PARP1 (0.40) | PARP1KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7394964 | 0.76 | DRD2 (0.42) | PARP1KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9822704 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1062144-A | The preparation method of benzodihydropyran carboxamide derivatives | DELAGRANGE LAB (FR) | 1992-06-24 | — | — | CN | claimed |
| EP-0231139-B1 | DIHYDROBENZOFURANE AND CHROMANE CARBOXAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS NEUROLEPTICS | Laboratoires DELAGRANGE (FR) | 1991-12-04 | — | — | EP | claimed |
| CN-1062144-A | The preparation method of benzodihydropyran carboxamide derivatives | DELAGRANGE LAB (FR) | 1992-06-24 | — | — | CN | disclosed |
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | disclosed |
| CN-87100978-A | Dihydrobenzofuran-and chroman-carboxamide derivatives, processes for their preparation and their use as neuroleptics | — | 1987-09-16 | — | — | CN | disclosed |