Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825542 | 0.92 | SMN1; SMN2 (0.37) | SMN1; SMN2ACACBALDH1A1HPGD | |
| SCHEMBL9825575 | 0.91 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1KDM4EGRIN1GRIN2B | |
| SCHEMBL9825436 | 0.90 | PIK3CA (0.35) | SMN1; SMN2ACACBALDH1A1GRIN1GRIN2B | |
| SCHEMBL9825803 | 0.88 | MCHR1 (0.34) | SMN1; SMN2ALDH1A1TP53GRIN2B | |
| SCHEMBL9825905 | 0.86 | ALDH1A1 (0.38) | ALDH1A1KDM4E | |
| SCHEMBL9827149 | 0.86 | ALDH1A1 (0.37) | ALDH1A1KDM4EGRIN1GRIN2B | |
| SCHEMBL9826520 | 0.84 | CNR2 (0.34) | KDM4E | |
| SCHEMBL9825690 | 0.84 | ALDH1A1 (0.39) | ACACBALDH1A1KDM4E | |
| SCHEMBL9827456 | 0.83 | ALDH1A1 (0.39) | ALDH1A1KDM4ETP53GAA | |
| SCHEMBL8880116 | 0.83 | ADRB2 (0.36) | POLBTBXAS1ALDH1A1MAPTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239815-B1 | SUBSTITUTED THIAZOLES AND OXAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1991-07-24 | — | — | EP | disclosed |