Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | PTK2B | Q14289 | 1/20 | 1.00 |
| ▸ | CASP3 | P42574 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | F12 | P00748 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979433 | 0.90 | SMN1; SMN2 (0.82) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL29350605 | 0.89 | SMN1; SMN2 (0.80) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL18216694 | 0.89 | SMN1; SMN2 (0.80) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL980106 | 0.88 | RAB9A (0.78) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL980173 | 0.87 | SMN1; SMN2 (0.77) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL32664390 | 0.85 | CASP3 (1.00) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL979418 | 0.85 | CASP3 (1.00) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL978553 | 0.83 | CASP3 (0.81) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL980334 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL25312016 | 0.79 | ALDH1A1 (0.81) | SMN1; SMN2RAB9ANPC1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021522-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021522-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | CASP7, CASP3, CASP6 | SMN1; SMN2 1555/4885RAB9A 3095/4885NPC1 2565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.