Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.56 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | CPA1 | P15085 | 1/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | KYNU | Q16719 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27215388 | 0.93 | LMNA (0.60) | LMNAMAPTALDH1A1GAAITGA4 | |
| SCHEMBL27213561 | 0.93 | LMNA (0.60) | LMNAMAPTALDH1A1GAAITGA4 | |
| SCHEMBL30070644 | 0.86 | LMNA (0.60) | LMNAMAPTALDH1A1ALOX15CTSL | |
| SCHEMBL7378641 | 0.85 | ALDH1A1 (0.54) | LMNAMAPTALDH1A1GAAITGA4 | |
| SCHEMBL6958952 | 0.85 | CTSK (0.54) | ALDH1A1ALOX15ITGB3ITGA2BCTSL | |
| SCHEMBL7438594 | 0.84 | TRPM8 (0.51) | LMNAMAPTALDH1A1GAAITGA4 | |
| SCHEMBL5401540 | 0.84 | ITGA4 (0.61) | ALDH1A1GAAITGA4ITGB7ALOX15 | |
| SCHEMBL9827227 | 0.84 | MAPT (0.62) | LMNAMAPTGAACTSLCTSK | |
| SCHEMBL8889717 | 0.83 | TYR (0.55) | ALDH1A1ALOX15ITGB3ITGA2BMME | |
| SCHEMBL9825831 | 0.83 | TYR (0.55) | ALDH1A1ALOX15ITGB3ITGA2BMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1230175-A | Cytostatic hydroximic acid derivatives | BRITISH BIOTECH PHARM (GB) | 1999-09-29 | — | — | CN | disclosed |
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |