Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5670687 | 0.83 | ALDH1A1 (0.56) | BRD4HSD17B10PARP1MAPK1ALDH1A1 | |
| SCHEMBL9826121 | 0.80 | KMT2A (0.57) | BRD4HSD17B10ALOX15PARP1MAPK1 | |
| SCHEMBL2101384 | 0.78 | L3MBTL1 (0.63) | HSD17B10ALOX15MAPK1USP2GAA | |
| SCHEMBL9827097 | 0.77 | PPARG (0.53) | BRD4HSD17B10ALOX15PARP1ALDH1A1 | |
| SCHEMBL9825998 | 0.75 | MAOB (0.63) | BRD4HSD17B10ALOX15PARP1MAPK1 | |
| SCHEMBL17434397 | 0.73 | KMT2A (0.67) | BRD4HSD17B10ALOX15MAPK1ALDH1A1 | |
| SCHEMBL5799536 | 0.73 | USP2 (0.76) | HSD17B10USP2GAAMEN1KMT2A | |
| SCHEMBL24124663 | 0.72 | THRB (0.41) | HSD17B10ALOX15ALDH1A1MEN1KMT2A | |
| SCHEMBL9826341 | 0.72 | USP2 (0.46) | BRD4HSD17B10ALOX15PARP1MAPK1 | |
| SCHEMBL2104033 | 0.72 | PARP1 (0.60) | BRD4PARP1USP2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283036-B1 | BENZOXAZINE DERIVATIVES AND PROCESSES FOR PREPARATION THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |
| US-4824833-A | ANTIDIABETIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0283036-A1 | Benzoxazine derivatives and processes for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1988-09-21 | — | — | EP | disclosed |