SCHEMBL9826699

SCHEMBL9826699

CC(C)(C)NC(=O)C(=O)c1ccccc1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.48
TSHR P16473 2/20 0.48
KDM4E B2RXH2 8/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
GAA P10253 2/20 0.46
MPO P05164 1/20 0.46
HIF1A Q16665 1/20 0.46
HPGD P15428 7/20 0.45
ALDH1A1 P00352 6/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
HMGB1 P09429 1/20 0.45
CA4 P22748 1/20 0.45
CA6 P23280 1/20 0.45
CA7 P43166 1/20 0.45
CA9 Q16790 1/20 0.45
NAPRT Q6XQN6 1/20 0.45
CA14 Q9ULX7 1/20 0.45
CYP2C9 P11712 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7757842 0.81 KDM4E (0.59) LMNATSHRKDM4ESMN1; SMN2GAA
SCHEMBL28590614 0.80 CES2 (0.59) TSHRSMN1; SMN2HPGDALDH1A1CYP2C9
Bromide SCHEMBL6849900 0.79 KDM4E (0.57) LMNATSHRKDM4ESMN1; SMN2GAA
SCHEMBL11471653 0.79 SMN1; SMN2 (0.42) LMNATSHRSMN1; SMN2GAAALDH1A1
SCHEMBL6745300 0.79 LMNA (0.53) LMNATSHRKDM4ESMN1; SMN2GAA
SCHEMBL11474339 0.77 PLK1 (0.53) LMNATSHRKDM4ESMN1; SMN2GAA
SCHEMBL11480899 0.77 CTSD (0.51) TSHRSMN1; SMN2GAAHPGDHSD17B10
SCHEMBL28596965 0.76 ALDH1A1 (0.56) TSHRKDM4ESMN1; SMN2GAAHPGD
SCHEMBL9797513 0.75 KDM4E (0.67) LMNATSHRKDM4ESMN1; SMN2GAA
SCHEMBL29861559 0.75 KDM4E (0.67) LMNATSHRKDM4ESMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0221346-B1 (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE WARNER-LAMBERT COMPANY (US) 1991-01-30 EP claimed
EP-0221346-B1 (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE WARNER-LAMBERT COMPANY (US) 1991-01-30 EP disclosed