Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 10/20 | 0.61 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.53 |
| ▸ | PNLIP | P16233 | 3/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826824 | 0.85 | ALOX15 (0.75) | ALOX15KLKB1PNLIPMEN1NPC1 | |
| SCHEMBL9826900 | 0.78 | ALOX15 (1.00) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL9826484 | 0.76 | ALOX15 (0.76) | ALOX15NPC1RAB9A | |
| SCHEMBL9826705 | 0.72 | ALOX15 (0.69) | ALOX15KLKB1PNLIPMEN1NPC1 | |
| SCHEMBL14289118 | 0.72 | KLKB1 (0.72) | ALOX15KLKB1PNLIPABCG2MEN1 | |
| SCHEMBL5080078 | 0.71 | PNLIP (0.91) | PNLIPMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9826365 | 0.71 | ALOX15 (1.00) | ALOX15KLKB1NPC1RAB9ALMNA | |
| SCHEMBL9827298 | 0.71 | KLKB1 (0.62) | ALOX15KLKB1PNLIPABCG2MEN1 | |
| SCHEMBL9826567 | 0.71 | THRB (0.54) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL26628392 | 0.69 | ALDH1A1 (0.58) | ALOX15KLKB1PNLIPABCG2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | claimed |