Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 4/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PIEZO1 | Q92508 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL915530 | 0.74 | NPC1 (0.38) | NPC1PKMRAB9AHSD17B10TERT | |
| SCHEMBL100765 | 0.72 | HPGDS (0.46) | HPGDSLTA4H | |
| SCHEMBL29454745 | 0.72 | NISCH (0.50) | NISCHNPC1PKMRAB9AKDM4E | |
| SCHEMBL78566 | 0.72 | NISCH (0.50) | NISCHNPC1PKMRAB9AKDM4E | |
| SCHEMBL29598957 | 0.72 | NISCH (0.50) | NISCHNPC1PKMRAB9AKDM4E | |
| SCHEMBL2570955 | 0.72 | CDK2 (0.36) | HPGDSNPC1PKMRAB9ALTA4H | |
| SCHEMBL17701242 | 0.72 | HPGDS (0.35) | HPGDSLTA4HCCNCCDK8 | |
| SCHEMBL6264053 | 0.72 | TERT (0.38) | NISCHNPC1PKMRAB9AKDM4E | |
| SCHEMBL12677958 | 0.72 | CCNC (0.38) | HPGDSLTA4HCCNCCDK8 | |
| SCHEMBL28733962 | 0.71 | HPGDS (0.34) | HPGDSLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119032092-A | Pyrazinone derivative and application thereof in medicine | 西藏海思科制药有限公司 | 2024-11-26 | — | — | CN | claimed |
| WO-2023202687-A1 | PYRAZINONE DERIVATIVE AND USE THEREOF IN MEDICINE | 四川海思科制药有限公司 | 2023-10-26 | — | — | WO | claimed |
| CN-116217558-A | GLP-1 receptor agonist, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-06-06 | — | — | CN | claimed |
| CN-115515956-A | Benzimidazole derivative and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-12-23 | — | — | CN | claimed |
| CN-113559006-A | A cosmetic composition for scavenging free radicals and resisting aging | 河南农业大学 | 2021-10-29 | — | — | CN | claimed |
| CN-104603165-B | Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for producing polymerizable compound | 日本瑞翁株式会社 | 2017-04-26 | — | — | CN | claimed |
| US-20150252050-A1 | NEW SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2015-09-10 | — | — | US | claimed |
| CN-103819509-A | Preparation method for novel Ru (II) complex containing-benzobenzoxazole and pyrazino [1,10] phenanthroline and anticancer activity of novel Ru (II) complex | UNIV JIANGNAN | 2014-05-28 | — | — | CN | claimed |
| US-20130184256-A1 | NEW SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-18 | — | — | US | claimed |
| EP-1899330-B9 | SUBSTITUTED GLYCINAMIDES HAVING AN ANTITHROMBOTIC AND FACTOR XA-INHIBITING EFFECT | BOEHRINGER INGELHEIM INT (DE) | 2011-11-09 | — | — | EP | claimed |
| EP-1899330-B1 | SUBSTITUTED GLYCINAMIDES HAVING AN ANTITHROMBOTIC AND FACTOR XA-INHIBITING EFFECT | BOEHRINGER INGELHEIM INT (DE) | 2010-11-24 | — | — | EP | claimed |
| US-20100216769-A1 | SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-26 | — | — | US | claimed |
| US-20080269280-A1 | OXO-IMIDAZOLIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2008-10-30 | — | — | US | claimed |
| WO-2007073432-A2 | PIPERIDINE DERIVATIVES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-06-28 | — | — | WO | claimed |
| US-20070093467-A1 | Piperidine derivatives and methods of use | CHEMOCENTRYX, INC. (US) | 2007-04-26 | — | — | US | claimed |
| US-20070088036-A1 | Piperidine derivatives and methods of use | CHEMOCENTRYX, INC. (US) | 2007-04-19 | — | — | US | claimed |
| WO-2007044804-A2 | PIPERIDINE DERIVATIVES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| WO-2007044885-A2 | PIPERIDINE DERIVATIVES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| WO-2007027734-A2 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX, INC. (US) | 2007-03-08 | — | — | WO | claimed |
| US-20060074121-A1 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2006-04-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074121-A1 | Bicyclic and bridged nitrogen heterocycles | CCR3, CCR1, CCR2 | HPGDS 199/4885NISCH 1965/4885NPC1 604/4885 |
| US-20100216769-A1 | SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS | PGM2, MGAM, GNMT | HPGDS 2472/4885NISCH 2073/4885NPC1 2779/4885 |
| US-20070093467-A1 | Piperidine derivatives and methods of use | CCR1, CCR3, CCR4 | HPGDS 67/4885NISCH 1782/4885NPC1 620/4885 |
| US-20130184256-A1 | NEW SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS | PGM2, MGAM, GRM1 | HPGDS 2270/4885NISCH 2216/4885NPC1 2812/4885 |
| US-20070088036-A1 | Piperidine derivatives and methods of use | CCR1, CCR3, CCR4 | HPGDS 67/4885NISCH 1782/4885NPC1 620/4885 |
| US-20080269280-A1 | OXO-IMIDAZOLIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | CCR1, CCR3, CCR4 | HPGDS 146/4885NISCH 1698/4885NPC1 842/4885 |
| US-20150252050-A1 | NEW SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS | PGM2, MGAM, GRM1 | HPGDS 2270/4885NISCH 2216/4885NPC1 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.