Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10676571 | 0.82 | SIRT6 (0.60) | MAPTPOLBALDH1A1LMNAGAA | |
| SCHEMBL9829274 | 0.81 | SLC18A3 (0.40) | SLC18A3PARP1HRH3 | |
| SCHEMBL9828971 | 0.81 | CA2 (0.42) | NPSR1PARP1MEN1KMT2A | |
| SCHEMBL9827933 | 0.79 | SLC18A3 (0.46) | SLC18A3MAPTPOLBL3MBTL1MAPK1 | |
| SCHEMBL9828873 | 0.76 | ALDH1A1 (0.40) | MAPTMAPK1ALDH1A1LMNAGAA | |
| SCHEMBL426360 | 0.75 | SLC18A3 (0.58) | SLC18A3MAPTPOLBL3MBTL1MAPK1 | |
| SCHEMBL9827139 | 0.74 | POLB (0.54) | SLC18A3MAPTPOLBMAPK1ALDH1A1 | |
| SCHEMBL22324857 | 0.70 | SLC18A3 (0.47) | SLC18A3MAPTPOLBMAPK1ALDH1A1 | |
| SCHEMBL1066991 | 0.70 | SLC18A3 (0.57) | SLC18A3MAPTPOLBALDH1A1LMNA | |
| SCHEMBL15911925 | 0.70 | SLC18A3 (0.57) | SLC18A3MAPTPOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291210-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-4835165-A | Antiarrhythmic 4-phenylpiperidines | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0291210-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-11-17 | — | — | EP | disclosed |