Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10679776 | 0.83 | FLT3 (0.46) | ALDH1A1LMNAMAPTSMN1; SMN2JAK2 | |
| SCHEMBL9828971 | 0.81 | CA2 (0.42) | TP53PARP1GPR119 | |
| SCHEMBL9828877 | 0.80 | JAK2 (0.39) | ALDH1A1LMNATP53MAPTATM | |
| SCHEMBL9829274 | 0.79 | SLC18A3 (0.40) | HRH3PARP1 | |
| SCHEMBL9828313 | 0.77 | JAK2 (0.47) | ALDH1A1LMNATP53MAPTATM | |
| SCHEMBL9828240 | 0.76 | SLC18A3 (0.45) | ALDH1A1LMNAMAPTHRH3GAA | |
| SCHEMBL319380 | 0.73 | KEAP1 (0.52) | ALDH1A1LMNATP53MAPTATM | |
| SCHEMBL22324953 | 0.73 | ROCK2 (0.40) | ALDH1A1LMNATP53MAPTATM | |
| SCHEMBL26154175 | 0.70 | ALDH1A1 (0.56) | ALDH1A1LMNATP53MAPTATM | |
| SCHEMBL20354737 | 0.70 | IDO1 (0.48) | ALDH1A1LMNATP53MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291210-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-4835165-A | Antiarrhythmic 4-phenylpiperidines | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0291210-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-11-17 | — | — | EP | disclosed |