Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829274 | 0.83 | SLC18A3 (0.40) | PARP1 | |
| SCHEMBL9828873 | 0.81 | ALDH1A1 (0.40) | PARP1TP53GPR119 | |
| SCHEMBL9828240 | 0.81 | SLC18A3 (0.45) | PARP1MEN1KMT2ANPSR1 | |
| SCHEMBL9828015 | 0.74 | CHRNA7 (0.50) | CA2CA1CA12CA9CA7 | |
| SCHEMBL9827723 | 0.70 | CHRNA7 (0.48) | CA2CA1CA12CA9CA7 | |
| SCHEMBL8323422 | 0.70 | CA2 (0.52) | CA2CA1CA12CA9CA7 | |
| SCHEMBL9830556 | 0.68 | CA1 (0.63) | CA2CA1CA12CA9CA7 | |
| SCHEMBL8343036 | 0.68 | CA1 (0.63) | CA2CA1CA12CA9CA7 | |
| SCHEMBL6841898 | 0.67 | CHRNA7 (0.59) | CA2CA1CA12CA9CA7 | |
| SCHEMBL22816328 | 0.66 | ESR2 (0.55) | CA2CA1CA12CA9CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291210-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-4835165-A | Antiarrhythmic 4-phenylpiperidines | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0291210-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-11-17 | — | — | EP | disclosed |