Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.54 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827840 | 0.82 | CA2 (0.58) | CA2RAPGEF4CA12CA9CA1 | |
| SCHEMBL9830133 | 0.80 | CA2 (0.49) | CA2RAPGEF4CA12CA9CA1 | |
| SCHEMBL9829067 | 0.79 | CA2 (0.70) | CA2GAAALDH1A1 | |
| SCHEMBL9831048 | 0.74 | CA2 (0.43) | CA2RAPGEF4CA12CA9CA1 | |
| SCHEMBL10649624 | 0.74 | CA2 (0.43) | CA2CA12CA9CA1 | |
| SCHEMBL9831469 | 0.74 | CA2 (0.63) | CA2CA12CA9CA1GAA | |
| SCHEMBL10388063 | 0.69 | CA2 (0.54) | CA2CA12CA9CA1CA7 | |
| SCHEMBL8493545 | 0.68 | GAA (0.60) | CA2RAPGEF4CA12CA9CA1 | |
| SCHEMBL8908176 | 0.68 | GAA (0.60) | CA2RAPGEF4CA12CA9CA1 | |
| SCHEMBL9424674 | 0.67 | CA2 (0.42) | CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |