Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306381 | 0.78 | CBFB (0.59) | PDE5A | |
| SCHEMBL9828781 | 0.78 | MCHR1 (0.43) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL716477 | 0.74 | CBFB (0.54) | PDE5AMCHR1 | |
| SCHEMBL2485757 | 0.72 | MCHR1 (0.58) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL9052784 | 0.71 | MCHR1 (0.57) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10485069 | 0.71 | PDE5A (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13738023 | 0.70 | MCHR1 (0.63) | MCHR1 | |
| SCHEMBL9828070 | 0.70 | CHEK2 (0.47) | — | |
| SCHEMBL9828063 | 0.70 | SLC6A2 (0.43) | PDE4APDE4D | |
| SCHEMBL13596760 | 0.69 | ADRB3 (0.50) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240158-B1 | BENZIMIDAZOLE DERIVATIVES | TOKYO TANABE COMPANY LIMITED (JP) | 1991-04-03 | — | — | EP | claimed |
| EP-0240158-A1 | Benzimidazole derivatives | TOKYO TANABE COMPANY LIMITED (JP) | 1987-10-07 | — | — | EP | claimed |