Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17087122 | 0.81 | LMNA (0.41) | ALDH1A1NPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL6844667 | 0.81 | ALDH1A1 (0.57) | ALDH1A1NPC1RAB9AHSD17B10L3MBTL1 | |
| SCHEMBL240012 | 0.79 | ALDH1A1 (0.60) | ALDH1A1NPC1RAB9AHSD17B10L3MBTL1 | |
| SCHEMBL5273762 | 0.79 | ADRB2 (0.62) | ALDH1A1LMNAHTTADRB2CYP3A4 | |
| SCHEMBL15713089 | 0.76 | KDM4E (0.36) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL19526213 | 0.76 | HTR2A (0.44) | ALDH1A1L3MBTL1SMN1; SMN2POLBKDM4E | |
| SCHEMBL1794510 | 0.74 | ALDH1A1 (0.54) | ALDH1A1HSD17B10L3MBTL1HPGDPOLB | |
| SCHEMBL19986733 | 0.73 | ADRB2 (0.67) | ALDH1A1HPGDPOLBKDM4ELMNA | |
| SCHEMBL17542783 | 0.73 | SMN1; SMN2 (0.45) | ALDH1A1NPC1RAB9AHSD17B10L3MBTL1 | |
| SCHEMBL2273801 | 0.72 | ADRB1 (0.58) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |