Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833771 | 0.84 | MAPT (0.38) | ALDH1A1KDM4EMAPTRAB9AHSD17B10 | |
| SCHEMBL9830583 | 0.84 | MAPT (0.38) | ALDH1A1KDM4EMAPTRAB9AHSD17B10 | |
| SCHEMBL9832663 | 0.84 | TDP2 (0.51) | ALDH1A1KDM4EMAPTL3MBTL1TDP2 | |
| SCHEMBL9832401 | 0.82 | MAPT (0.33) | ALDH1A1KDM4EMAPTL3MBTL1NPC1 | |
| SCHEMBL9834567 | 0.80 | ALDH1A1 (0.35) | ALDH1A1KDM4EMAPTL3MBTL1TDP2 | |
| SCHEMBL4270503 | 0.76 | TP53 (0.45) | ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL4850477 | 0.76 | MAPT (0.44) | ALDH1A1KDM4EMAPTL3MBTL1KMT2A | |
| SCHEMBL15075740 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTHSD17B10KMT2A | |
| SCHEMBL9833467 | 0.76 | CDYL2 (0.48) | KMT2A | |
| SCHEMBL7681777 | 0.74 | MAPT (0.58) | ALDH1A1KDM4EMAPTL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |
| CN-85103724-B | Process for preparing pyrrolobenzimidazoles | 曼海姆伯灵格股份公司 | 1988-07-06 | — | — | CN | disclosed |
| CN-85103724-A | The method for preparing novel pyrrolo-benzoglyoxaline | — | 1986-07-02 | — | — | CN | disclosed |