Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 2/20 | 0.49 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830213 | 0.93 | BCHE (0.49) | MEP1BCALM1CAMKK2BCHEACHE | |
| SCHEMBL9831156 | 0.88 | TSHR (0.45) | MEP1BKDM4EALDH1A1LTA4H | |
| SCHEMBL9830592 | 0.87 | KMT2A (0.44) | MEP1BPPARGPPARAALDH1A1KMT2A | |
| SCHEMBL9831172 | 0.85 | USP2 (0.46) | MEP1BBCHEACHEKDM4EALDH1A1 | |
| SCHEMBL9829350 | 0.85 | ALOX5 (0.50) | BCHEACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL2061494 | 0.83 | MEP1B (0.56) | MEP1BCALM1CAMKK2BCHEACHE | |
| SCHEMBL8423493 | 0.82 | CALM1 (0.64) | MEP1BCALM1CAMKK2BCHEACHE | |
| SCHEMBL10407429 | 0.82 | ALDH1A1 (0.52) | BCHEACHEKDM4EALDH1A1MEN1 | |
| SCHEMBL9829851 | 0.81 | HSD17B10 (0.51) | TSPOKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2062287 | 0.81 | CALM1 (0.62) | MEP1BCALM1CAMKK2BCHECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |