Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829350 | 0.88 | ALOX5 (0.50) | KMT2AALOX5LTA4HSMN1; SMN2NPC1 | |
| SCHEMBL9830799 | 0.87 | MEP1B (0.49) | KMT2AMEP1BLTA4HPPARGPPARA | |
| SCHEMBL9831206 | 0.84 | SMN1; SMN2 (0.46) | KMT2AMEP1BALOX5LTA4HSMN1; SMN2 | |
| SCHEMBL14325933 | 0.84 | TAS2R14 (0.49) | MEP1BPPARGPPARANPC1JAK2 | |
| SCHEMBL10232316 | 0.82 | MEP1B (0.50) | KMT2AMEP1BLTA4HPPARGPPARA | |
| SCHEMBL4321470 | 0.81 | SMN1; SMN2 (0.51) | KMT2AALOX5LTA4HSMN1; SMN2NPC1 | |
| SCHEMBL9830890 | 0.81 | SMN1; SMN2 (0.43) | KMT2AALOX5LTA4HSMN1; SMN2ALDH1A1 | |
| SCHEMBL10407429 | 0.81 | ALDH1A1 (0.52) | KMT2AALDH1A1 | |
| SCHEMBL9324850 | 0.80 | SMN1; SMN2 (0.55) | KMT2AALOX5LTA4HSMN1; SMN2NPC1 | |
| SCHEMBL10232375 | 0.80 | TAS2R14 (0.52) | MEP1BPPARGPPARANPC1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |