Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982930 | 0.84 | MAPT (0.52) | KMT2AMEN1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL9832213 | 0.81 | LTA4H (0.44) | KMT2AMEN1LTA4HALDH1A1CCNA2 | |
| SCHEMBL7369952 | 0.81 | ALDH1A1 (0.48) | LMNAL3MBTL1ALDH1A1CDK2 | |
| SCHEMBL9832465 | 0.81 | KMT2A (0.49) | KMT2AMEN1 | |
| SCHEMBL7399203 | 0.79 | NPC1 (0.54) | KMT2AMEN1LMNANPSR1ALDH1A1 | |
| SCHEMBL5821548 | 0.76 | PTPN1 (0.35) | KMT2AMEN1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL9832118 | 0.73 | POLB (0.51) | KMT2ANPSR1ALDH1A1CDK2 | |
| SCHEMBL9831962 | 0.73 | PARP1 (0.47) | KMT2AMEN1ALDH1A1CCNA2CDK2 | |
| SCHEMBL5793588 | 0.72 | KMT2A (0.49) | KMT2ALMNANAPRTKDM4EL3MBTL1 | |
| SCHEMBL523863 | 0.72 | MAPT (0.49) | KMT2AMEN1LMNANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129846-B1 | (3-AMINO-1H-PYRAZOL-4-YL)(ARYL)METHANONES | AMERICAN CYANAMID COMPANY (US) | 1991-05-08 | — | — | EP | claimed |
| US-4980472-A | REACTING ACETONITRILE DERIVATIVE WITH AMINOGUANIDINE DERIVATIVE | AMERICAN CYANAMID COMPANY (US) | 1990-12-25 | — | — | US | claimed |
| US-4900836-A | (3-amino-1H-pyrazol-4-yl) (aryl)methanones | AMERICAN CYANAMID COMPANY (US) | 1990-02-13 | — | — | US | claimed |
| EP-0129846-A2 | (3-Amino-1H-pyrazol-4-yl)(aryl)methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | claimed |