Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399203 | 0.84 | NPC1 (0.54) | ALDH1A1LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL9832465 | 0.83 | KMT2A (0.49) | MAPTSMN1; SMN2NPC1SRD5A2MAPK1 | |
| SCHEMBL9832213 | 0.83 | LTA4H (0.44) | ALDH1A1MAPTCDK2SMN1; SMN2NPC1 | |
| SCHEMBL3982930 | 0.83 | MAPT (0.52) | ALDH1A1LMNAMAPTGAACCNE2 | |
| SCHEMBL9832118 | 0.81 | POLB (0.51) | ALDH1A1MAPTGAACCNE2CCNE1 | |
| SCHEMBL9830883 | 0.81 | KMT2A (0.44) | ALDH1A1LMNAL3MBTL1CDK2 | |
| SCHEMBL6274897 | 0.78 | NOS3 (0.37) | ALDH1A1MAPTCCNE2CCNE1CDK2 | |
| SCHEMBL9831766 | 0.77 | TSHR (0.58) | ALDH1A1LMNAMAPTL3MBTL1GAA | |
| SCHEMBL5821548 | 0.74 | PTPN1 (0.35) | ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL9831105 | 0.74 | TUBB1 (0.49) | MAPTGAANPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129846-B1 | (3-AMINO-1H-PYRAZOL-4-YL)(ARYL)METHANONES | AMERICAN CYANAMID COMPANY (US) | 1991-05-08 | — | — | EP | claimed |
| EP-0129846-A2 | (3-Amino-1H-pyrazol-4-yl)(aryl)methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | claimed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |