Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369952 | 0.83 | ALDH1A1 (0.48) | ALDH1A1HTTCES2CES1NPC1 | |
| SCHEMBL9832465 | 0.83 | KMT2A (0.49) | HTTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL3982930 | 0.83 | MAPT (0.52) | MAPK14ALDH1A1CCNA2CDK2MEN1 | |
| SCHEMBL9831962 | 0.81 | PARP1 (0.47) | MAPK14ALDH1A1HTTCES2CES1 | |
| SCHEMBL9830883 | 0.81 | KMT2A (0.44) | LTA4HALDH1A1CCNA2CDK2MEN1 | |
| SCHEMBL7399203 | 0.81 | NPC1 (0.54) | MAPK14ALDH1A1HTTCES2CES1 | |
| SCHEMBL9830186 | 0.75 | ALDH1A1 (0.46) | MAPK14ALDH1A1CES2CES1NPC1 | |
| SCHEMBL5821548 | 0.74 | PTPN1 (0.35) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL9831766 | 0.74 | TSHR (0.58) | ALDH1A1HTTMEN1KMT2ACDK5 | |
| SCHEMBL9832146 | 0.72 | SRD5A2 (0.50) | ALDH1A1CES2CCNA2CDK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129846-B1 | (3-AMINO-1H-PYRAZOL-4-YL)(ARYL)METHANONES | AMERICAN CYANAMID COMPANY (US) | 1991-05-08 | — | — | EP | claimed |
| EP-0129846-A2 | (3-Amino-1H-pyrazol-4-yl)(aryl)methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | claimed |
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |