Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.32 |
| ▸ | YAP1 | P46937 | 1/20 | 0.32 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.32 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833086 | 0.88 | NPC1 (0.38) | MAPTKMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL9834177 | 0.81 | MAPT (0.42) | MAPTKMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL9833650 | 0.80 | MAPT (0.41) | MAPTKMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL9832757 | 0.76 | TUBB4A (0.38) | MAPTKMT2ALMNAALDH1A1HPGD | |
| SCHEMBL9831796 | 0.68 | NPC1 (0.35) | MAPTKMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL9832379 | 0.68 | NPC1 (0.35) | MAPTALDH1A1HPGDESR1RAB9A | |
| SCHEMBL3883354 | 0.65 | CA12 (0.52) | MAPTKMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL15368479 | 0.65 | ESR1 (0.49) | MAPTKMT2AALDH1A1ESR1TSHR | |
| SCHEMBL9808062 | 0.64 | TEAD1 (0.53) | MAPTKMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL6975653 | 0.63 | KIF11 (0.40) | MAPTKMT2ALMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1021051-C | THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING SAME | TANABE SEIYAKU CO (JP) | 1993-06-02 | — | — | CN | disclosed |
| EP-0297782-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-22 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| CN-1030584-A | Novel thiophene derivant and preparation method thereof | TANABE SEIYAKU CO (JP) | 1989-01-25 | — | — | CN | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |